Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 166903..167474 Replicon chromosome
Accession NC_013928
Organism Streptococcus mutans NN2025

Toxin (Protein)


Gene name mazF Uniprot ID A0A2J9QC66
Locus tag SMUNN2025_RS00815 Protein ID WP_002265705.1
Coordinates 167142..167474 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2J9QC51
Locus tag SMUNN2025_RS00810 Protein ID WP_002264866.1
Coordinates 166903..167148 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMUNN2025_RS00775 162411..163157 + 747 WP_002264862.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -
SMUNN2025_RS00780 163181..164041 + 861 WP_002269065.1 DegV family protein -
SMUNN2025_RS00785 164173..164688 + 516 WP_002265708.1 hypothetical protein -
SMUNN2025_RS00790 164688..165134 + 447 WP_002269854.1 hypothetical protein -
SMUNN2025_RS00795 165131..165325 + 195 WP_002262994.1 helix-turn-helix transcriptional regulator -
SMUNN2025_RS00800 165718..166164 + 447 WP_002262993.1 50S ribosomal protein L13 -
SMUNN2025_RS00805 166189..166581 + 393 WP_002262992.1 30S ribosomal protein S9 -
SMUNN2025_RS00810 166903..167148 + 246 WP_002264866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SMUNN2025_RS00815 167142..167474 + 333 WP_002265705.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SMUNN2025_RS00820 167673..168464 - 792 Protein_143 DUF4037 domain-containing protein -
SMUNN2025_RS10450 168631..168984 + 354 Protein_144 transposase family protein -
SMUNN2025_RS00825 169166..170386 + 1221 WP_002262024.1 PTS sugar transporter subunit IIC -
SMUNN2025_RS00830 170364..171212 + 849 WP_002265112.1 alpha/beta hydrolase -
SMUNN2025_RS00835 171354..171956 + 603 WP_002269739.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 168631..168759 128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

Antitoxin PemI-like

(1-81)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12664.56 Da        Isoelectric Point: 6.4634

>T24596 WP_002265705.1 NC_013928:167142-167474 [Streptococcus mutans NN2025]
MVTIKQGSIIKINLDPKQGHEQKGYRPYICLNHSIVTKYSNIAIFAPISNTKRDYPFYVPLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG

Download         Length: 333 bp

>T24596 NC_013928:167142-167474 [Streptococcus mutans NN2025]
ATGGTAACCATCAAGCAAGGGTCAATTATCAAAATTAACTTGGATCCCAAACAAGGACATGAACAAAAAGGGTATCGTCC
GTACATTTGTCTAAATCATAGTATCGTAACCAAGTATTCTAATATTGCTATTTTTGCGCCAATTAGCAATACCAAGCGTG
ATTACCCTTTTTATGTTCCCCTAGAAGGAACAGAATCCACAGGGAAAGTATTATTAGACCAACTGGTTACAATTGATTTT
AATGCTAGAGATTATCGTTATGTGGAGGATATTCAGGAAGACTTATTAGATGAACTTTTAGCTAGGGTCAAAGTGCTATT
TGAAAAAGGATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9255.55 Da        Isoelectric Point: 4.3021

>AT24596 WP_002264866.1 NC_013928:166903-167148 [Streptococcus mutans NN2025]
MQLVINKWGNSSAIRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNVPELTVEDLFKDYQGEPVNVTPVLFESVGNEQ
W

Download         Length: 246 bp

>AT24596 NC_013928:166903-167148 [Streptococcus mutans NN2025]
ATGCAACTAGTCATCAATAAATGGGGAAATAGCTCCGCTATTCGTTTGCCAAAACAATTGGTACAAGAATTACAATTACA
AACAAATGATGTCTTAGACTATAAGGTATCAGGGAATAAAATTATCCTAGAAAAAGTGAATAATGTCCCTGAATTAACTG
TAGAAGATCTGTTTAAAGATTATCAAGGTGAACCTGTCAATGTTACCCCAGTTCTATTTGAAAGTGTGGGAAATGAACAA
TGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QC66

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9QC51

References