Detailed information of TA system TA024596

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 166903..167474
• Replicon: chromosome
• Accession: NC_013928
• Organism: Streptococcus mutans NN2025

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A0A2J9QC66
• Locus tag: SMUNN2025_RS00815
• Protein ID: WP_002265705.1
• Coordinates: 167142..167474 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A2J9QC51
• Locus tag: SMUNN2025_RS00810
• Protein ID: WP_002264866.1
• Coordinates: 166903..167148 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMUNN2025_RS00775	162411..163157	+	747	WP_002264862.1	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	-
SMUNN2025_RS00780	163181..164041	+	861	WP_002269065.1	DegV family protein	-
SMUNN2025_RS00785	164173..164688	+	516	WP_002265708.1	hypothetical protein	-
SMUNN2025_RS00790	164688..165134	+	447	WP_002269854.1	hypothetical protein	-
SMUNN2025_RS00795	165131..165325	+	195	WP_002262994.1	helix-turn-helix transcriptional regulator	-
SMUNN2025_RS00800	165718..166164	+	447	WP_002262993.1	50S ribosomal protein L13	-
SMUNN2025_RS00805	166189..166581	+	393	WP_002262992.1	30S ribosomal protein S9	-
SMUNN2025_RS00810	166903..167148	+	246	WP_002264866.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SMUNN2025_RS00815	167142..167474	+	333	WP_002265705.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
SMUNN2025_RS00820	167673..168464	-	792	Protein_143	DUF4037 domain-containing protein	-
SMUNN2025_RS10450	168631..168984	+	354	Protein_144	transposase family protein	-
SMUNN2025_RS00825	169166..170386	+	1221	WP_002262024.1	PTS sugar transporter subunit IIC	-
SMUNN2025_RS00830	170364..171212	+	849	WP_002265112.1	alpha/beta hydrolase	-
SMUNN2025_RS00835	171354..171956	+	603	WP_002269739.1	NAD(P)H-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	168631..168759	128

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (5-107)

Antitoxin

• Antitoxin PemI-like (1-81)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12664.56 Da
• Isoelectric Point: 6.4634

>T24596 WP_002265705.1 NC_013928:167142-167474 [Streptococcus mutans NN2025]
MVTIKQGSIIKINLDPKQGHEQKGYRPYICLNHSIVTKYSNIAIFAPISNTKRDYPFYVPLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG

Nucleotide

• Length: 333 bp

>T24596 NC_013928:167142-167474 [Streptococcus mutans NN2025]
ATGGTAACCATCAAGCAAGGGTCAATTATCAAAATTAACTTGGATCCCAAACAAGGACATGAACAAAAAGGGTATCGTCC
GTACATTTGTCTAAATCATAGTATCGTAACCAAGTATTCTAATATTGCTATTTTTGCGCCAATTAGCAATACCAAGCGTG
ATTACCCTTTTTATGTTCCCCTAGAAGGAACAGAATCCACAGGGAAAGTATTATTAGACCAACTGGTTACAATTGATTTT
AATGCTAGAGATTATCGTTATGTGGAGGATATTCAGGAAGACTTATTAGATGAACTTTTAGCTAGGGTCAAAGTGCTATT
TGAAAAAGGATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9255.55 Da
• Isoelectric Point: 4.3021

>AT24596 WP_002264866.1 NC_013928:166903-167148 [Streptococcus mutans NN2025]
MQLVINKWGNSSAIRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNVPELTVEDLFKDYQGEPVNVTPVLFESVGNEQ
W

Nucleotide

• Length: 246 bp

>AT24596 NC_013928:166903-167148 [Streptococcus mutans NN2025]
ATGCAACTAGTCATCAATAAATGGGGAAATAGCTCCGCTATTCGTTTGCCAAAACAATTGGTACAAGAATTACAATTACA
AACAAATGATGTCTTAGACTATAAGGTATCAGGGAATAAAATTATCCTAGAAAAAGTGAATAATGTCCCTGAATTAACTG
TAGAAGATCTGTTTAAAGATTATCAAGGTGAACCTGTCAATGTTACCCCAGTTCTATTTGAAAGTGTGGGAAATGAACAA
TGGTAA

Structures

Toxin

• AlphaFold DB: A0A2J9QC66

Antitoxin

• AlphaFold DB: A0A2J9QC51