Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | SmuAT/- |
| Location | 164173..165134 | Replicon | chromosome |
| Accession | NC_013928 | ||
| Organism | Streptococcus mutans NN2025 | ||
Toxin (Protein)
| Gene name | smuT | Uniprot ID | - |
| Locus tag | SMUNN2025_RS00785 | Protein ID | WP_002265708.1 |
| Coordinates | 164173..164688 (+) | Length | 172 a.a. |
Antitoxin (Protein)
| Gene name | smuA | Uniprot ID | A0A829BWH5 |
| Locus tag | SMUNN2025_RS00790 | Protein ID | WP_002269854.1 |
| Coordinates | 164688..165134 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SMUNN2025_RS00760 | 159590..160327 | + | 738 | WP_002263001.1 | MerR family transcriptional regulator | - |
| SMUNN2025_RS00765 | 160363..161355 | - | 993 | WP_041160307.1 | BtrH N-terminal domain-containing protein | - |
| SMUNN2025_RS00770 | 161544..162098 | - | 555 | WP_002264861.1 | PadR family transcriptional regulator | - |
| SMUNN2025_RS00775 | 162411..163157 | + | 747 | WP_002264862.1 | 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB | - |
| SMUNN2025_RS00780 | 163181..164041 | + | 861 | WP_002269065.1 | DegV family protein | - |
| SMUNN2025_RS00785 | 164173..164688 | + | 516 | WP_002265708.1 | hypothetical protein | Toxin |
| SMUNN2025_RS00790 | 164688..165134 | + | 447 | WP_002269854.1 | hypothetical protein | Antitoxin |
| SMUNN2025_RS00795 | 165131..165325 | + | 195 | WP_002262994.1 | helix-turn-helix transcriptional regulator | - |
| SMUNN2025_RS00800 | 165718..166164 | + | 447 | WP_002262993.1 | 50S ribosomal protein L13 | - |
| SMUNN2025_RS00805 | 166189..166581 | + | 393 | WP_002262992.1 | 30S ribosomal protein S9 | - |
| SMUNN2025_RS00810 | 166903..167148 | + | 246 | WP_002264866.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| SMUNN2025_RS00815 | 167142..167474 | + | 333 | WP_002265705.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| SMUNN2025_RS00820 | 167673..168464 | - | 792 | Protein_143 | DUF4037 domain-containing protein | - |
| SMUNN2025_RS10450 | 168631..168984 | + | 354 | Protein_144 | transposase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 168631..168759 | 128 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 172 a.a. Molecular weight: 19562.22 Da Isoelectric Point: 9.8654
>T24595 WP_002265708.1 NC_013928:164173-164688 [Streptococcus mutans NN2025]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCHSILNDAYFTARKNKKFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCHSILNDAYFTARKNKKFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK
Download Length: 516 bp
>T24595 NC_013928:164173-164688 [Streptococcus mutans NN2025]
ATGTTTGACCTTGTTGTTAATTTGATTTTATTGGTTATTGTGATAGGTGGATTTGTCTTCTTAAGATTCTATGCGGATAA
GAAAGGCAAGCGAGAATACGATGAACGCCAGTTACTTATGCAAAAGAAAGCTTATACCAATGCGGCTTGGGTTGTTATGG
GTTTCAATCTTGTTCTTGTGATATGGGGTGAAGTGTTAGCAAAATATATCTCGCTATCCTTTGCAGGTACTGCCAATCTC
TTTCTTATCGTAGGCGTCTTTGTCTGCCACAGTATCTTAAACGATGCTTATTTCACAGCAAGAAAAAACAAAAAATTCCT
CTATGTGTATGCCGTTATTATTGCTATTCAAATTTTCACTGTTTATCAAAATTGGAGTCAAGGCAGCTTTGGTCATGACG
GACATATTTATCTAACAGGAGAAAAAGCAATGAGTTTATTGTTTATCTTGACTTTTGCTGTCATTTTTCTAGTAACTGCT
TATAAAACGATTCAGGATAAGAGAGAGGGAAAGTGA
ATGTTTGACCTTGTTGTTAATTTGATTTTATTGGTTATTGTGATAGGTGGATTTGTCTTCTTAAGATTCTATGCGGATAA
GAAAGGCAAGCGAGAATACGATGAACGCCAGTTACTTATGCAAAAGAAAGCTTATACCAATGCGGCTTGGGTTGTTATGG
GTTTCAATCTTGTTCTTGTGATATGGGGTGAAGTGTTAGCAAAATATATCTCGCTATCCTTTGCAGGTACTGCCAATCTC
TTTCTTATCGTAGGCGTCTTTGTCTGCCACAGTATCTTAAACGATGCTTATTTCACAGCAAGAAAAAACAAAAAATTCCT
CTATGTGTATGCCGTTATTATTGCTATTCAAATTTTCACTGTTTATCAAAATTGGAGTCAAGGCAGCTTTGGTCATGACG
GACATATTTATCTAACAGGAGAAAAAGCAATGAGTTTATTGTTTATCTTGACTTTTGCTGTCATTTTTCTAGTAACTGCT
TATAAAACGATTCAGGATAAGAGAGAGGGAAAGTGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16998.26 Da Isoelectric Point: 9.5767
>AT24595 WP_002269854.1 NC_013928:164688-165134 [Streptococcus mutans NN2025]
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESITKCSYLGLSGFWLICMGASIVYRHYLDKKEADK
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESITKCSYLGLSGFWLICMGASIVYRHYLDKKEADK
Download Length: 447 bp
>AT24595 NC_013928:164688-165134 [Streptococcus mutans NN2025]
ATGAAAATGGAAAAGTCAAATAAACAAGTCATTTACGATGAACGTCAGCAGCAAATTCAACTTAAAAGTTATAGTCTTTC
ATTTTGGTTTGTTATGTTTATACTCTATTTTGCAACTTTTGGAAAGACTGATTTGTTGCTTAATATCGCTTTTTGGGGAG
GACTTGTTCTTAATTTTTGCTACAGTACTCTAAGAGGTGTTGGTCCTTTTGTTGATCCACGTTTTGGAAAAATTGCAAAA
ATCGGTCGTTTGGCCGCTGTTCCCCTTATTTTTTTGGGAATGCTAGTCTTTCTTGTTGCTATCATAATGTCTATTCTAGA
ACATGATAGTTTAAGAGAATCTATCACAAAATGCTCCTACTTAGGCTTATCTGGTTTTTGGCTAATTTGTATGGGAGCAA
GTATCGTCTACCGTCATTATCTTGATAAGAAAGAAGCAGACAAATGA
ATGAAAATGGAAAAGTCAAATAAACAAGTCATTTACGATGAACGTCAGCAGCAAATTCAACTTAAAAGTTATAGTCTTTC
ATTTTGGTTTGTTATGTTTATACTCTATTTTGCAACTTTTGGAAAGACTGATTTGTTGCTTAATATCGCTTTTTGGGGAG
GACTTGTTCTTAATTTTTGCTACAGTACTCTAAGAGGTGTTGGTCCTTTTGTTGATCCACGTTTTGGAAAAATTGCAAAA
ATCGGTCGTTTGGCCGCTGTTCCCCTTATTTTTTTGGGAATGCTAGTCTTTCTTGTTGCTATCATAATGTCTATTCTAGA
ACATGATAGTTTAAGAGAATCTATCACAAAATGCTCCTACTTAGGCTTATCTGGTTTTTGGCTAATTTGTATGGGAGCAA
GTATCGTCTACCGTCATTATCTTGATAAGAAAGAAGCAGACAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|