Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 183333..184084 Replicon plasmid unnamed2
Accession NZ_CP097690
Organism Klebsiella pneumoniae strain IR12079_1

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag M3X89_RS29280 Protein ID WP_014386536.1
Coordinates 183333..183815 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag M3X89_RS29285 Protein ID WP_004902250.1
Coordinates 183806..184084 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X89_RS29260 (M3X89_29260) 179732..180379 - 648 WP_014386537.1 EcsC family protein -
M3X89_RS29265 (M3X89_29265) 180406..181161 - 756 WP_004902235.1 DUF2971 domain-containing protein -
M3X89_RS29270 (M3X89_29270) 181262..181654 - 393 WP_032442757.1 hypothetical protein -
M3X89_RS29275 (M3X89_29275) 181759..182298 - 540 WP_004902239.1 hypothetical protein -
M3X89_RS29280 (M3X89_29280) 183333..183815 - 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
M3X89_RS29285 (M3X89_29285) 183806..184084 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
M3X89_RS29290 (M3X89_29290) 184203..184415 - 213 WP_004902255.1 hypothetical protein -
M3X89_RS29295 (M3X89_29295) 184523..184864 - 342 WP_004902257.1 hypothetical protein -
M3X89_RS29300 (M3X89_29300) 185694..186152 - 459 WP_014386535.1 hypothetical protein -
M3X89_RS29305 (M3X89_29305) 186805..187260 - 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
M3X89_RS29310 (M3X89_29310) 187332..187697 + 366 WP_001294656.1 mercuric ion transporter MerT -
M3X89_RS29315 (M3X89_29315) 187713..187988 + 276 WP_000732275.1 mercury resistance system periplasmic binding protein MerP -
M3X89_RS29320 (M3X89_29320) 188016..188441 + 426 WP_000522996.1 organomercurial transporter MerC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr iucA / iucB / iucC / iucD / iutA / rmpA2 1..230866 230866


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T245949 WP_014386536.1 NZ_CP097690:c183815-183333 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT245949 WP_004902250.1 NZ_CP097690:c184084-183806 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References