Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 58967..59877 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP097690 | ||
| Organism | Klebsiella pneumoniae strain IR12079_1 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | M3X89_RS28635 | Protein ID | WP_004026354.1 |
| Coordinates | 59407..59877 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | M3X89_RS28630 | Protein ID | WP_004181895.1 |
| Coordinates | 58967..59410 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M3X89_RS28615 (M3X89_28615) | 55600..57087 | + | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
| M3X89_RS28620 (M3X89_28620) | 57173..57595 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| M3X89_RS28625 (M3X89_28625) | 57595..58866 | + | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| M3X89_RS28630 (M3X89_28630) | 58967..59410 | + | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| M3X89_RS28635 (M3X89_28635) | 59407..59877 | + | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| M3X89_RS28640 (M3X89_28640) | 59987..60247 | - | 261 | WP_004026352.1 | hypothetical protein | - |
| M3X89_RS28645 (M3X89_28645) | 60970..61128 | + | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| M3X89_RS28650 (M3X89_28650) | 61731..62705 | + | 975 | WP_014386572.1 | hypothetical protein | - |
| M3X89_RS28655 (M3X89_28655) | 62903..63280 | - | 378 | WP_004181901.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr | iucA / iucB / iucC / iucD / iutA / rmpA2 | 1..230866 | 230866 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T245947 WP_004026354.1 NZ_CP097690:59407-59877 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT245947 WP_004181895.1 NZ_CP097690:58967-59410 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |