Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 1114..1636 Replicon plasmid unnamed2
Accession NZ_CP097690
Organism Klebsiella pneumoniae strain IR12079_1

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag M3X89_RS28390 Protein ID WP_004181778.1
Coordinates 1352..1636 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag M3X89_RS28385 Protein ID WP_004181777.1
Coordinates 1114..1362 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X89_RS28380 (M3X89_28380) 553..768 - 216 WP_250203265.1 AAA family ATPase -
M3X89_RS28385 (M3X89_28385) 1114..1362 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M3X89_RS28390 (M3X89_28390) 1352..1636 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M3X89_RS28395 (M3X89_28395) 1653..1754 - 102 Protein_4 IS200/IS605 family transposase -
M3X89_RS28400 (M3X89_28400) 1790..3015 + 1226 Protein_5 transposase -
M3X89_RS28405 (M3X89_28405) 3285..3508 - 224 Protein_6 transposase -
M3X89_RS28410 (M3X89_28410) 3587..4015 - 429 WP_077257669.1 IS200/IS605 family transposase -
M3X89_RS28415 (M3X89_28415) 4051..5242 + 1192 Protein_8 transposase -
M3X89_RS28420 (M3X89_28420) 5645..5989 - 345 WP_223811496.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr iucA / iucB / iucC / iucD / iutA / rmpA2 1..230866 230866


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T245946 WP_004181778.1 NZ_CP097690:1352-1636 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT245946 WP_004181777.1 NZ_CP097690:1114-1362 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References