Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4991977..4992493 Replicon chromosome
Accession NZ_CP097688
Organism Klebsiella pneumoniae strain IR12079_1

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag M3X89_RS24985 Protein ID WP_002886902.1
Coordinates 4991977..4992261 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M3X89_RS24990 Protein ID WP_002886901.1
Coordinates 4992251..4992493 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X89_RS24960 (M3X89_24960) 4987462..4987725 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
M3X89_RS24965 (M3X89_24965) 4987855..4988028 + 174 WP_002886906.1 hypothetical protein -
M3X89_RS24970 (M3X89_24970) 4988031..4988774 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M3X89_RS24975 (M3X89_24975) 4989131..4991268 + 2138 Protein_4907 anaerobic ribonucleoside-triphosphate reductase -
M3X89_RS24980 (M3X89_24980) 4991509..4991973 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M3X89_RS24985 (M3X89_24985) 4991977..4992261 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M3X89_RS24990 (M3X89_24990) 4992251..4992493 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M3X89_RS24995 (M3X89_24995) 4992571..4994481 - 1911 WP_004152270.1 PRD domain-containing protein -
M3X89_RS25000 (M3X89_25000) 4994504..4995658 - 1155 WP_002886900.1 lactonase family protein -
M3X89_RS25005 (M3X89_25005) 4995724..4996464 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T245942 WP_002886902.1 NZ_CP097688:c4992261-4991977 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT245942 WP_002886901.1 NZ_CP097688:c4992493-4992251 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References