Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4887621..4888431 Replicon chromosome
Accession NZ_CP097688
Organism Klebsiella pneumoniae strain IR12079_1

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag M3X89_RS24485 Protein ID WP_002887280.1
Coordinates 4887621..4888154 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag M3X89_RS24490 Protein ID WP_002887278.1
Coordinates 4888165..4888431 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X89_RS24480 (M3X89_24480) 4886452..4887573 + 1122 WP_002887282.1 cupin domain-containing protein -
M3X89_RS24485 (M3X89_24485) 4887621..4888154 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
M3X89_RS24490 (M3X89_24490) 4888165..4888431 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
M3X89_RS24495 (M3X89_24495) 4888534..4889967 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
M3X89_RS24500 (M3X89_24500) 4889957..4890640 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
M3X89_RS24505 (M3X89_24505) 4890812..4892197 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
M3X89_RS24510 (M3X89_24510) 4892215..4892559 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T245941 WP_002887280.1 NZ_CP097688:c4888154-4887621 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT245941 WP_002887278.1 NZ_CP097688:c4888431-4888165 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References