Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 914056..914710 Replicon chromosome
Accession NZ_CP097688
Organism Klebsiella pneumoniae strain IR12079_1

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag M3X89_RS04695 Protein ID WP_004144731.1
Coordinates 914303..914710 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M3X89_RS04690 Protein ID WP_002916312.1
Coordinates 914056..914322 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X89_RS04665 (M3X89_04665) 909212..910645 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
M3X89_RS04670 (M3X89_04670) 910764..911492 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M3X89_RS04675 (M3X89_04675) 911542..911853 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
M3X89_RS04680 (M3X89_04680) 912017..912676 + 660 WP_002916317.1 hemolysin III family protein -
M3X89_RS04685 (M3X89_04685) 912827..913810 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
M3X89_RS04690 (M3X89_04690) 914056..914322 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M3X89_RS04695 (M3X89_04695) 914303..914710 + 408 WP_004144731.1 protein YgfX Toxin
M3X89_RS04700 (M3X89_04700) 914717..915238 - 522 WP_002916308.1 flavodoxin FldB -
M3X89_RS04705 (M3X89_04705) 915339..916235 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M3X89_RS04710 (M3X89_04710) 916258..916971 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M3X89_RS04715 (M3X89_04715) 916977..918710 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T245934 WP_004144731.1 NZ_CP097688:914303-914710 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT245934 WP_002916312.1 NZ_CP097688:914056-914322 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References