Detailed information of TA system TA024593

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1626585..1627036
• Replicon: chromosome
• Accession: NC_013895
• Organism: Clostridiales genomosp. BVAB3 str. UPII9-5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HMPREF0868_RS06995
• Protein ID: WP_081470284.1
• Coordinates: 1626875..1627036 (+)
• Length: 54 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D3R076
• Locus tag: HMPREF0868_RS06990
• Protein ID: WP_012994034.1
• Coordinates: 1626585..1626869 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMPREF0868_RS06970	1623812..1624516	-	705	WP_012994031.1	DUF448 domain-containing protein	-
HMPREF0868_RS06975	1624500..1625618	-	1119	WP_012994032.1	transcription termination/antitermination protein NusA	-
HMPREF0868_RS06980	1625675..1626142	-	468	WP_012994033.1	ribosome maturation factor RimP	-
HMPREF0868_RS06990	1626585..1626869	+	285	WP_012994034.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HMPREF0868_RS06995	1626875..1627036	+	162	WP_081470284.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HMPREF0868_RS07000	1627188..1627598	+	411	WP_012994035.1	hypothetical protein	-
HMPREF0868_RS07005	1627813..1629375	-	1563	WP_012994036.1	ABC transporter substrate-binding protein	-
HMPREF0868_RS07010	1629393..1630052	-	660	WP_012994037.1	ABC transporter ATP-binding protein	-
HMPREF0868_RS07015	1630052..1631257	-	1206	WP_012994038.1	ABC transporter permease	-
HMPREF0868_RS07020	1631365..1631817	-	453	WP_012994039.1	DUF4418 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-48)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-71)

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6448.65 Da
• Isoelectric Point: 10.1030

>T24593 WP_081470284.1 NC_013895:1626875-1627036 [Mageeibacillus indolicus UPII9-5]
MLQIQTTSKFRKDYKRIKKRGLDIYLLKEVLDKLCARETLDLKYKDHADLFNM

Nucleotide

• Length: 162 bp

>T24593 NC_013895:1626875-1627036 [Mageeibacillus indolicus UPII9-5]
ATGCTTCAAATCCAAACGACATCCAAGTTCCGTAAGGACTACAAGCGCATCAAAAAGCGAGGTCTTGACATCTATTTACT
CAAAGAAGTCCTTGACAAACTCTGTGCTAGGGAAACGCTAGACCTTAAATACAAAGACCACGCTGACCTATTTAACATGT
AA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10442.92 Da
• Isoelectric Point: 4.7863

>AT24593 WP_012994034.1 NC_013895:1626585-1626869 [Mageeibacillus indolicus UPII9-5]
MAKTANINVRIEPEVKQNAEDLFGSFGISVTDAINIFLRTSIMEGGFPFTIKQPRFNAETLAAMQEARDIMSGKIQAKSY
KTTDEILKALNTED

Nucleotide

• Length: 285 bp

>AT24593 NC_013895:1626585-1626869 [Mageeibacillus indolicus UPII9-5]
ATGGCTAAAACTGCAAACATCAATGTCCGTATTGAACCCGAAGTTAAACAAAACGCTGAAGATCTTTTTGGTAGCTTTGG
TATCTCTGTAACAGATGCCATCAATATTTTCTTGCGTACATCCATTATGGAAGGTGGTTTCCCTTTCACAATCAAGCAAC
CAAGATTTAATGCTGAAACACTGGCAGCAATGCAAGAAGCACGTGACATCATGTCCGGTAAGATTCAAGCCAAATCCTAT
AAAACCACAGATGAGATTCTTAAAGCACTCAATACAGAGGACTAG

Structures

Antitoxin

• AlphaFold DB: D3R076