Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1562..2151 Replicon plasmid unnamed1
Accession NZ_CP097684
Organism Klebsiella pneumoniae strain IR12073_1

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag M3X91_RS26980 Protein ID WP_250203242.1
Coordinates 1828..2151 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag M3X91_RS26975 Protein ID WP_000093040.1
Coordinates 1562..1840 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X91_RS26960 (M3X91_26960) 135..380 + 246 WP_032440458.1 hypothetical protein -
M3X91_RS26965 (M3X91_26965) 654..1025 + 372 WP_001237044.1 cell envelope integrity protein TolA -
M3X91_RS26970 (M3X91_26970) 1022..1387 + 366 WP_072354022.1 TonB family protein -
M3X91_RS26975 (M3X91_26975) 1562..1840 + 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
M3X91_RS26980 (M3X91_26980) 1828..2151 + 324 WP_250203242.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M3X91_RS26985 (M3X91_26985) 2304..2732 + 429 WP_001140599.1 hypothetical protein -
M3X91_RS26990 (M3X91_26990) 2758..2937 + 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
M3X91_RS26995 (M3X91_26995) 2964..3494 - 531 WP_071177729.1 hypothetical protein -
M3X91_RS27000 (M3X91_27000) 3501..4232 - 732 WP_071177728.1 MobC family replication-relaxation protein -
M3X91_RS27005 (M3X91_27005) 4232..6196 - 1965 WP_071177727.1 TraM recognition domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10832 10832


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12191.11 Da        Isoelectric Point: 10.3092

>T245922 WP_250203242.1 NZ_CP097684:1828-2151 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGQTASNNR

Download         Length: 324 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT245922 WP_000093040.1 NZ_CP097684:1562-1840 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References