Detailed information of TA system TA024592

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 180807..181366
• Replicon: chromosome
• Accession: NC_013895
• Organism: Clostridiales genomosp. BVAB3 str. UPII9-5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D3QZD1
• Locus tag: HMPREF0868_RS00755
• Protein ID: WP_012992799.1
• Coordinates: 180807..181094 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D3QZD0
• Locus tag: HMPREF0868_RS00760
• Protein ID: WP_012992800.1
• Coordinates: 181091..181366 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMPREF0868_RS00735	178095..179156	+	1062	WP_012992794.1	hypothetical protein	-
HMPREF0868_RS00740	179149..179370	-	222	WP_012992795.1	hypothetical protein	-
HMPREF0868_RS00745	179358..180245	-	888	WP_081470210.1	IS3 family transposase	-
HMPREF0868_RS00750	180176..180738	-	563	Protein_141	helix-turn-helix domain-containing protein	-
HMPREF0868_RS00755	180807..181094	-	288	WP_012992799.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HMPREF0868_RS00760	181091..181366	-	276	WP_012992800.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HMPREF0868_RS00765	181488..181688	+	201	WP_012992801.1	hypothetical protein	-
HMPREF0868_RS00770	181690..181950	+	261	WP_012992802.1	helix-turn-helix domain-containing protein	-
HMPREF0868_RS00775	181993..182457	+	465	WP_012992803.1	ImmA/IrrE family metallo-endopeptidase	-
HMPREF0868_RS08165	182983..185091	+	2109	WP_081470211.1	glucosaminidase domain-containing protein	-
HMPREF0868_RS00800	185321..186328	+	1008	WP_012992807.1	aspartate--ammonia ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-93)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-88)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11162.85 Da
• Isoelectric Point: 8.1208

>T24592 WP_012992799.1 NC_013895:c181094-180807 [Mageeibacillus indolicus UPII9-5]
MSKHLDIVWTNQFKKDYKLAMKRHLDIDLLDDIIRKLASSEQLPEKNKDHALSGNWVGHRECHIQPDWLLVYRIENNLLV
LTLSRTGTHSDLFGK

Nucleotide

• Length: 288 bp

>T24592 NC_013895:c181094-180807 [Mageeibacillus indolicus UPII9-5]
ATGAGTAAACATTTAGACATTGTTTGGACAAATCAATTTAAGAAGGACTACAAGCTGGCGATGAAACGGCATCTTGATAT
TGACCTTCTGGACGACATCATTCGCAAACTGGCAAGCAGCGAACAACTTCCAGAAAAGAATAAAGACCACGCTTTAAGCG
GAAACTGGGTCGGGCATCGTGAGTGCCACATTCAGCCAGATTGGCTATTGGTCTATCGCATCGAGAATAATTTGCTCGTC
TTGACATTATCCCGAACAGGAACGCACAGCGATTTATTTGGAAAGTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10330.89 Da
• Isoelectric Point: 5.1743

>AT24592 WP_012992800.1 NC_013895:c181366-181091 [Mageeibacillus indolicus UPII9-5]
MATTTNFSVRMDSEIKKQCEAMYGELGINLTTAINVFLRQSLRVGGFPFDVRMEQPNKETMAAMLEAERIARDPSVKRYA
DVEEALRALKE

Nucleotide

• Length: 276 bp

>AT24592 NC_013895:c181366-181091 [Mageeibacillus indolicus UPII9-5]
ATGGCTACCACAACTAATTTCAGTGTCCGTATGGACAGTGAAATTAAGAAACAGTGCGAAGCAATGTATGGTGAATTAGG
TATCAACCTTACTACCGCTATCAATGTGTTTCTCCGCCAGTCGCTCCGGGTCGGCGGTTTTCCTTTTGATGTTCGCATGG
AGCAGCCGAACAAGGAAACGATGGCAGCAATGCTAGAAGCGGAACGCATTGCCCGTGATCCATCTGTAAAACGCTACGCT
GATGTAGAGGAAGCATTGCGGGCGTTGAAAGAATGA

Structures

Toxin

• AlphaFold DB: D3QZD1

Antitoxin

• AlphaFold DB: D3QZD0