Detailed information of TA system TA024591

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 133826..134379
• Replicon: chromosome
• Accession: NC_013895
• Organism: Clostridiales genomosp. BVAB3 str. UPII9-5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D3QZG8
• Locus tag: HMPREF0868_RS00570
• Protein ID: WP_012992761.1
• Coordinates: 133826..134104 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D3QZG7
• Locus tag: HMPREF0868_RS00575
• Protein ID: WP_012992762.1
• Coordinates: 134104..134379 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMPREF0868_RS07735	129617..130360	+	744	WP_012992755.1	TlpA family protein disulfide reductase	-
HMPREF0868_RS00550	130371..131159	+	789	WP_041705649.1	TlpA family protein disulfide reductase	-
HMPREF0868_RS00555	131356..132543	+	1188	WP_012992757.1	glycine C-acetyltransferase	-
HMPREF0868_RS00560	132710..133144	+	435	WP_012992758.1	DNA starvation/stationary phase protection protein	-
HMPREF0868_RS00565	133311..133631	+	321	WP_012992759.1	helix-turn-helix domain-containing protein	-
HMPREF0868_RS00570	133826..134104	-	279	WP_012992761.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HMPREF0868_RS00575	134104..134379	-	276	WP_012992762.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HMPREF0868_RS00580	134776..135525	-	750	WP_012992763.1	Bax inhibitor-1/YccA family protein	-
HMPREF0868_RS00585	135768..136616	+	849	WP_012992764.1	NTP transferase domain-containing protein	-
HMPREF0868_RS00590	136618..137955	+	1338	WP_012992765.1	GTP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-71)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10733.51 Da
• Isoelectric Point: 8.0539

>T24591 WP_012992761.1 NC_013895:c134104-133826 [Mageeibacillus indolicus UPII9-5]
MYKIKFTNAYKKSYKRMAKRGISLSLLDEAVDNLRQGIALDPKYKDHILKGKFNGFHECHIKPDWLLVYLLEDDILTLTL
IDTGSHTDLFDM

Nucleotide

• Length: 279 bp

>T24591 NC_013895:c134104-133826 [Mageeibacillus indolicus UPII9-5]
ATGTATAAAATAAAGTTTACGAACGCATATAAGAAAAGCTATAAGCGTATGGCTAAACGGGGAATCAGCCTTTCTCTTTT
AGATGAAGCGGTAGATAACCTAAGACAAGGTATTGCGCTTGATCCTAAATACAAAGACCATATACTAAAAGGAAAATTCA
ACGGTTTTCACGAATGTCACATCAAACCGGATTGGTTACTTGTTTATCTACTAGAGGATGATATTCTCACCCTCACTCTT
ATCGATACTGGCAGTCACACAGACCTATTCGACATGTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10027.49 Da
• Isoelectric Point: 5.0642

>AT24591 WP_012992762.1 NC_013895:c134379-134104 [Mageeibacillus indolicus UPII9-5]
MATSPTQIRIDNNVKTEANELFSALGLDMSSAVNIFLRQCVLHGGLPFKVEIPKYNAETLAAMEEARKISKDPNAPSYSS
MEDLKKALLQD

Nucleotide

• Length: 276 bp

>AT24591 NC_013895:c134379-134104 [Mageeibacillus indolicus UPII9-5]
ATGGCAACAAGTCCTACTCAAATTCGTATTGATAATAATGTCAAAACAGAAGCAAATGAACTGTTTAGCGCACTTGGCCT
CGACATGTCAAGTGCCGTAAATATCTTCTTACGCCAATGCGTTTTGCACGGCGGTCTTCCCTTTAAGGTGGAAATCCCAA
AGTATAATGCTGAAACGCTGGCCGCTATGGAAGAAGCTAGAAAAATTTCCAAAGACCCTAACGCACCATCGTATTCTTCT
ATGGAAGACCTTAAGAAAGCGTTGTTGCAAGACTGA

Structures

Toxin

• AlphaFold DB: D3QZG8

Antitoxin

• AlphaFold DB: D3QZG7