Detailed information of TA system TA024590

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_19(antitoxin)
• Location: 2345981..2346771
• Replicon: chromosome
• Accession: NC_013893
• Organism: Staphylococcus lugdunensis HKU09-01

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: SLGD_RS11195
• Protein ID: WP_012991011.1
• Coordinates: 2346307..2346771 (+)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: SLGD_RS11190
• Protein ID: WP_012991010.1
• Coordinates: 2345981..2346295 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SLGD_RS11150	2341649..2342089	-	441	WP_012991001.1	single-stranded DNA-binding protein	-
SLGD_RS11155	2342086..2342760	-	675	WP_012991002.1	ERF family protein	-
SLGD_RS11160	2342761..2343246	-	486	WP_012991003.1	siphovirus Gp157 family protein	-
SLGD_RS11165	2343315..2343494	-	180	WP_041612466.1	hypothetical protein	-
SLGD_RS11170	2343722..2344324	+	603	WP_012991005.1	hypothetical protein	-
SLGD_RS11175	2344370..2345122	-	753	WP_012991006.1	phage antirepressor KilAC domain-containing protein	-
SLGD_RS11180	2345130..2345423	+	294	WP_049823122.1	hypothetical protein	-
SLGD_RS13285	2345416..2345577	-	162	WP_012991008.1	hypothetical protein	-
SLGD_RS11185	2345593..2345829	-	237	WP_012991009.1	helix-turn-helix domain-containing protein	-
SLGD_RS11190	2345981..2346295	+	315	WP_012991010.1	helix-turn-helix domain-containing protein	Antitoxin
SLGD_RS11195	2346307..2346771	+	465	WP_012991011.1	ImmA/IrrE family metallo-endopeptidase	Toxin
SLGD_RS13290	2346819..2346962	+	144	WP_012991012.1	hypothetical protein	-
SLGD_RS11200	2347095..2347277	+	183	WP_012991013.1	hypothetical protein	-
SLGD_RS11205	2347431..2348471	+	1041	WP_012991014.1	Abi family protein	-
SLGD_RS11210	2348540..2349922	+	1383	WP_012991015.1	recombinase family protein	-
SLGD_RS11215	2349952..2351142	+	1191	Protein_2192	FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2312214..2349922	37708

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• IrrE N-terminal-like domain (15-118)

Antitoxin

• Cro/C1-type helix-turn-helix domain (4-62)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 18312.92 Da
• Isoelectric Point: 6.6365

>T24590 WP_012991011.1 NC_013893:2346307-2346771 [Staphylococcus lugdunensis HKU09-01]
MGLYEKILIEHDYIEVRETDVMPNDLHGLWLGDLILIKRNLPETRKAEVLYEELAHHKLTYGNILGQSKWINRKFENYAK
RHGYEAALPLRIIVEAHHYGVSNLYELAQYVQLSEEHVLEILEHYKQKHGIGTHYGDYSITFEPLRVYKLHRFD

Nucleotide

• Length: 465 bp

>T24590 NC_013893:2346307-2346771 [Staphylococcus lugdunensis HKU09-01]
ATGGGGTTATATGAAAAAATTTTAATAGAGCATGACTATATAGAAGTTAGAGAAACAGATGTTATGCCTAATGACTTACA
CGGTTTATGGTTAGGTGATTTAATTCTAATTAAACGCAACCTACCCGAAACGCGCAAAGCCGAAGTTCTCTACGAAGAAT
TAGCACATCATAAACTTACATATGGGAATATCTTAGGCCAGTCTAAATGGATTAACCGTAAATTCGAAAACTACGCTAAA
CGTCACGGATACGAGGCAGCACTGCCTTTGCGTATTATCGTTGAGGCACATCATTACGGTGTAAGTAACTTATACGAACT
AGCACAGTATGTTCAATTAAGTGAAGAACATGTATTAGAAATATTGGAACATTACAAACAGAAACATGGTATTGGAACTC
ACTACGGCGATTACTCAATTACGTTTGAGCCGTTGAGAGTGTACAAATTGCATAGATTTGATTAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12073.64 Da
• Isoelectric Point: 7.1672

>AT24590 WP_012991010.1 NC_013893:2345981-2346295 [Staphylococcus lugdunensis HKU09-01]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAFLMGWIEETDEQPQHRAAHL
EGELTDEEWQRVLDYADYIRSKRK

Nucleotide

• Length: 315 bp

>AT24590 NC_013893:2345981-2346295 [Staphylococcus lugdunensis HKU09-01]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTAGCTGAACTAGGAAGAAAAATCGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGTGGAAATATCAAAAATCTTAAAAACGATACTATCGAAAGCATAGCTACGG
CATTAAATGTTAACCCTGCATTTTTGATGGGTTGGATAGAAGAAACTGATGAACAACCACAACATCGTGCAGCACATCTT
GAAGGGGAATTAACAGATGAAGAATGGCAACGCGTTCTAGATTATGCAGATTATATAAGAAGCAAACGTAAATAA