Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 2345981..2346771 Replicon chromosome
Accession NC_013893
Organism Staphylococcus lugdunensis HKU09-01

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag SLGD_RS11195 Protein ID WP_012991011.1
Coordinates 2346307..2346771 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag SLGD_RS11190 Protein ID WP_012991010.1
Coordinates 2345981..2346295 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SLGD_RS11150 2341649..2342089 - 441 WP_012991001.1 single-stranded DNA-binding protein -
SLGD_RS11155 2342086..2342760 - 675 WP_012991002.1 ERF family protein -
SLGD_RS11160 2342761..2343246 - 486 WP_012991003.1 siphovirus Gp157 family protein -
SLGD_RS11165 2343315..2343494 - 180 WP_041612466.1 hypothetical protein -
SLGD_RS11170 2343722..2344324 + 603 WP_012991005.1 hypothetical protein -
SLGD_RS11175 2344370..2345122 - 753 WP_012991006.1 phage antirepressor KilAC domain-containing protein -
SLGD_RS11180 2345130..2345423 + 294 WP_049823122.1 hypothetical protein -
SLGD_RS13285 2345416..2345577 - 162 WP_012991008.1 hypothetical protein -
SLGD_RS11185 2345593..2345829 - 237 WP_012991009.1 helix-turn-helix domain-containing protein -
SLGD_RS11190 2345981..2346295 + 315 WP_012991010.1 helix-turn-helix domain-containing protein Antitoxin
SLGD_RS11195 2346307..2346771 + 465 WP_012991011.1 ImmA/IrrE family metallo-endopeptidase Toxin
SLGD_RS13290 2346819..2346962 + 144 WP_012991012.1 hypothetical protein -
SLGD_RS11200 2347095..2347277 + 183 WP_012991013.1 hypothetical protein -
SLGD_RS11205 2347431..2348471 + 1041 WP_012991014.1 Abi family protein -
SLGD_RS11210 2348540..2349922 + 1383 WP_012991015.1 recombinase family protein -
SLGD_RS11215 2349952..2351142 + 1191 Protein_2192 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2312214..2349922 37708


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(15-118)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18312.92 Da        Isoelectric Point: 6.6365

>T24590 WP_012991011.1 NC_013893:2346307-2346771 [Staphylococcus lugdunensis HKU09-01]
MGLYEKILIEHDYIEVRETDVMPNDLHGLWLGDLILIKRNLPETRKAEVLYEELAHHKLTYGNILGQSKWINRKFENYAK
RHGYEAALPLRIIVEAHHYGVSNLYELAQYVQLSEEHVLEILEHYKQKHGIGTHYGDYSITFEPLRVYKLHRFD

Download         Length: 465 bp

>T24590 NC_013893:2346307-2346771 [Staphylococcus lugdunensis HKU09-01]
ATGGGGTTATATGAAAAAATTTTAATAGAGCATGACTATATAGAAGTTAGAGAAACAGATGTTATGCCTAATGACTTACA
CGGTTTATGGTTAGGTGATTTAATTCTAATTAAACGCAACCTACCCGAAACGCGCAAAGCCGAAGTTCTCTACGAAGAAT
TAGCACATCATAAACTTACATATGGGAATATCTTAGGCCAGTCTAAATGGATTAACCGTAAATTCGAAAACTACGCTAAA
CGTCACGGATACGAGGCAGCACTGCCTTTGCGTATTATCGTTGAGGCACATCATTACGGTGTAAGTAACTTATACGAACT
AGCACAGTATGTTCAATTAAGTGAAGAACATGTATTAGAAATATTGGAACATTACAAACAGAAACATGGTATTGGAACTC
ACTACGGCGATTACTCAATTACGTTTGAGCCGTTGAGAGTGTACAAATTGCATAGATTTGATTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12073.64 Da        Isoelectric Point: 7.1672

>AT24590 WP_012991010.1 NC_013893:2345981-2346295 [Staphylococcus lugdunensis HKU09-01]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAFLMGWIEETDEQPQHRAAHL
EGELTDEEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT24590 NC_013893:2345981-2346295 [Staphylococcus lugdunensis HKU09-01]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTAGCTGAACTAGGAAGAAAAATCGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGTGGAAATATCAAAAATCTTAAAAACGATACTATCGAAAGCATAGCTACGG
CATTAAATGTTAACCCTGCATTTTTGATGGGTTGGATAGAAGAAACTGATGAACAACCACAACATCGTGCAGCACATCTT
GAAGGGGAATTAACAGATGAAGAATGGCAACGCGTTCTAGATTATGCAGATTATATAAGAAGCAAACGTAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References