Detailed information of TA system TA024589

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2083536..2084074
• Replicon: chromosome
• Accession: NC_013893
• Organism: Staphylococcus lugdunensis HKU09-01

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: SLGD_RS09825
• Protein ID: WP_012990926.1
• Coordinates: 2083536..2083862 (-)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IA75
• Locus tag: SLGD_RS09830
• Protein ID: WP_001058492.1
• Coordinates: 2083865..2084074 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SLGD_RS09790	2078607..2078840	-	234	WP_012990919.1	hypothetical protein	-
SLGD_RS09795	2078854..2079195	-	342	WP_012990920.1	hypothetical protein	-
SLGD_RS09800	2079542..2080183	-	642	WP_012990921.1	hypothetical protein	-
SLGD_RS09805	2080180..2080464	-	285	WP_012990922.1	hypothetical protein	-
SLGD_RS09810	2080466..2080828	-	363	WP_012990923.1	hypothetical protein	-
SLGD_RS09815	2081114..2082583	-	1470	WP_012990924.1	virulence-associated E family protein	-
SLGD_RS09820	2082600..2083469	-	870	WP_012990925.1	primase alpha helix C-terminal domain-containing protein	-
SLGD_RS09825	2083536..2083862	-	327	WP_012990926.1	DUF1474 family protein	Toxin
SLGD_RS09830	2083865..2084074	-	210	WP_001058492.1	hypothetical protein	Antitoxin
SLGD_RS09835	2084067..2084213	-	147	WP_012990927.1	hypothetical protein	-
SLGD_RS09840	2084225..2084497	-	273	WP_012990928.1	helix-turn-helix domain-containing protein	-
SLGD_RS09845	2084498..2084710	-	213	WP_012990929.1	helix-turn-helix transcriptional regulator	-
SLGD_RS09850	2084854..2085555	+	702	WP_012990930.1	helix-turn-helix domain-containing protein	-
SLGD_RS09855	2085570..2086790	+	1221	WP_012990931.1	site-specific integrase	-
SLGD_RS09860	2086933..2087745	-	813	WP_002459651.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
SLGD_RS09865	2087767..2088462	-	696	WP_002479302.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2076197..2101694	25497

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 13003.62 Da
• Isoelectric Point: 6.0660

>T24589 WP_012990926.1 NC_013893:c2083862-2083536 [Staphylococcus lugdunensis HKU09-01]
MNWEIKNLFSDLKLLKDSFEDLKDNHGWHFDKFYPHEPNHVLNKTEAIKEGLSYHERRIHNNQMFDLFHLYIKQFDELIQ
KFHEIEKASSDVSLATESDDAKKLKITE

Nucleotide

• Length: 327 bp

>T24589 NC_013893:c2083862-2083536 [Staphylococcus lugdunensis HKU09-01]
ATGAATTGGGAAATTAAAAATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAATCATGG
TTGGCATTTTGATAAGTTTTATCCTCATGAACCTAATCATGTTTTAAATAAAACCGAAGCGATTAAAGAAGGACTTTCTT
ATCACGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAAAACAGTTCGATGAACTTATACAA
AAATTTCATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCAAAGAAATTAAAAATTAC
AGAGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8238.28 Da
• Isoelectric Point: 4.3718

>AT24589 WP_001058492.1 NC_013893:c2084074-2083865 [Staphylococcus lugdunensis HKU09-01]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT24589 NC_013893:c2084074-2083865 [Staphylococcus lugdunensis HKU09-01]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCATTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Antitoxin

• AlphaFold DB: X5IA75