Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 268716..269626 | Replicon | plasmid unnamed3 |
| Accession | NZ_CP097678 | ||
| Organism | Klebsiella pneumoniae strain IR12024_1 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A5Q9LR54 |
| Locus tag | M3T48_RS29730 | Protein ID | WP_004181896.1 |
| Coordinates | 268716..269186 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | M3T48_RS29735 | Protein ID | WP_004181895.1 |
| Coordinates | 269183..269626 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M3T48_RS29705 (M3T48_29705) | 263867..264244 | + | 378 | WP_004181901.1 | hypothetical protein | - |
| M3T48_RS29710 (M3T48_29710) | 264442..265416 | - | 975 | WP_004181899.1 | hypothetical protein | - |
| M3T48_RS29715 (M3T48_29715) | 266019..266177 | - | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| M3T48_RS29725 (M3T48_29725) | 268346..268606 | + | 261 | WP_004026352.1 | hypothetical protein | - |
| M3T48_RS29730 (M3T48_29730) | 268716..269186 | - | 471 | WP_004181896.1 | RES family NAD+ phosphorylase | Toxin |
| M3T48_RS29735 (M3T48_29735) | 269183..269626 | - | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| M3T48_RS29740 (M3T48_29740) | 269727..270998 | - | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| M3T48_RS29745 (M3T48_29745) | 270998..271420 | - | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| M3T48_RS29750 (M3T48_29750) | 271506..272993 | - | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..288415 | 288415 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17549.81 Da Isoelectric Point: 4.6155
>T245883 WP_004181896.1 NZ_CP097678:c269186-268716 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT245883 WP_004181895.1 NZ_CP097678:c269626-269183 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q9LR54 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |