Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 152668..153404 Replicon plasmid unnamed3
Accession NZ_CP097678
Organism Klebsiella pneumoniae strain IR12024_1

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag M3T48_RS29165 Protein ID WP_003026803.1
Coordinates 152668..153150 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag M3T48_RS29170 Protein ID WP_003026799.1
Coordinates 153138..153404 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3T48_RS29145 (M3T48_29145) 148196..149014 + 819 WP_004181718.1 phospholipase D family protein -
M3T48_RS29150 (M3T48_29150) 149418..149816 + 399 WP_004181717.1 H-NS family nucleoid-associated regulatory protein -
M3T48_RS29155 (M3T48_29155) 150403..151035 + 633 WP_001567369.1 hypothetical protein -
M3T48_RS29160 (M3T48_29160) 151064..152467 - 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
M3T48_RS29165 (M3T48_29165) 152668..153150 - 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
M3T48_RS29170 (M3T48_29170) 153138..153404 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
M3T48_RS29175 (M3T48_29175) 153649..153966 - 318 WP_224440782.1 cell envelope integrity protein TolA -
M3T48_RS29180 (M3T48_29180) 154020..155000 + 981 WP_000019445.1 IS5-like element ISKpn26 family transposase -
M3T48_RS29185 (M3T48_29185) 155146..155688 - 543 Protein_160 DEAD/DEAH box helicase -
M3T48_RS29190 (M3T48_29190) 155685..156986 - 1302 WP_148719203.1 ATP-binding protein -
M3T48_RS29195 (M3T48_29195) 157021..157626 - 606 WP_000509966.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..288415 288415
- inside IScluster/Tn - - 151064..160618 9554


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T245882 WP_003026803.1 NZ_CP097678:c153150-152668 [Klebsiella pneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT245882 WP_003026799.1 NZ_CP097678:c153404-153138 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References