Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5358187..5358812 Replicon chromosome
Accession NZ_CP097675
Organism Klebsiella pneumoniae strain IR12024_1

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag M3T48_RS26375 Protein ID WP_002882817.1
Coordinates 5358187..5358570 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag M3T48_RS26380 Protein ID WP_004150355.1
Coordinates 5358570..5358812 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3T48_RS26360 (M3T48_26360) 5355553..5356455 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
M3T48_RS26365 (M3T48_26365) 5356452..5357087 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
M3T48_RS26370 (M3T48_26370) 5357084..5358013 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
M3T48_RS26375 (M3T48_26375) 5358187..5358570 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
M3T48_RS26380 (M3T48_26380) 5358570..5358812 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
M3T48_RS26385 (M3T48_26385) 5359017..5359934 + 918 WP_002882812.1 alpha/beta hydrolase -
M3T48_RS26390 (M3T48_26390) 5359948..5360889 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
M3T48_RS26395 (M3T48_26395) 5360934..5361371 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
M3T48_RS26400 (M3T48_26400) 5361368..5362228 - 861 WP_002882807.1 virulence factor BrkB family protein -
M3T48_RS26405 (M3T48_26405) 5362222..5362821 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T245874 WP_002882817.1 NZ_CP097675:c5358570-5358187 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT245874 WP_004150355.1 NZ_CP097675:c5358812-5358570 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References