Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4877952..4878468 Replicon chromosome
Accession NZ_CP097675
Organism Klebsiella pneumoniae strain IR12024_1

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag M3T48_RS24070 Protein ID WP_002886902.1
Coordinates 4877952..4878236 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M3T48_RS24075 Protein ID WP_002886901.1
Coordinates 4878226..4878468 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3T48_RS24045 (M3T48_24045) 4873436..4873699 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
M3T48_RS24050 (M3T48_24050) 4873829..4874002 + 174 WP_002886906.1 hypothetical protein -
M3T48_RS24055 (M3T48_24055) 4874005..4874748 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M3T48_RS24060 (M3T48_24060) 4875105..4877243 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
M3T48_RS24065 (M3T48_24065) 4877484..4877948 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M3T48_RS24070 (M3T48_24070) 4877952..4878236 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M3T48_RS24075 (M3T48_24075) 4878226..4878468 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M3T48_RS24080 (M3T48_24080) 4878546..4880456 - 1911 WP_004152270.1 PRD domain-containing protein -
M3T48_RS24085 (M3T48_24085) 4880479..4881633 - 1155 WP_002886900.1 lactonase family protein -
M3T48_RS24090 (M3T48_24090) 4881699..4882439 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T245872 WP_002886902.1 NZ_CP097675:c4878236-4877952 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT245872 WP_002886901.1 NZ_CP097675:c4878468-4878226 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References