Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1005015..1005532 Replicon chromosome
Accession NC_013893
Organism Staphylococcus lugdunensis HKU09-01

Toxin (Protein)


Gene name mazF Uniprot ID A0A853V3R6
Locus tag SLGD_RS04605 Protein ID WP_002461192.1
Coordinates 1005182..1005532 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A853V233
Locus tag SLGD_RS04600 Protein ID WP_002461193.1
Coordinates 1005015..1005185 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SLGD_RS04575 1000840..1001322 + 483 WP_002478975.1 PH domain-containing protein -
SLGD_RS04580 1001315..1002829 + 1515 WP_002461198.1 PH domain-containing protein -
SLGD_RS04585 1002816..1003328 + 513 WP_002478976.1 PH domain-containing protein -
SLGD_RS04590 1003340..1003732 + 393 WP_002461196.1 holo-ACP synthase -
SLGD_RS04595 1003780..1004928 + 1149 WP_012990786.1 alanine racemase -
SLGD_RS04600 1005015..1005185 + 171 WP_002461193.1 hypothetical protein Antitoxin
SLGD_RS04605 1005182..1005532 + 351 WP_002461192.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SLGD_RS04610 1005966..1006967 + 1002 WP_002461191.1 PP2C family protein-serine/threonine phosphatase -
SLGD_RS04615 1007058..1007384 + 327 WP_002461190.1 anti-sigma factor antagonist -
SLGD_RS04620 1007386..1007865 + 480 WP_012990787.1 anti-sigma B factor RsbW -
SLGD_RS04625 1007840..1008610 + 771 WP_002461188.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13079.20 Da        Isoelectric Point: 9.9784

>T24587 WP_002461192.1 NC_013893:1005182-1005532 [Staphylococcus lugdunensis HKU09-01]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIGKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDHALDISLGLHNYH

Download         Length: 351 bp

>T24587 NC_013893:1005182-1005532 [Staphylococcus lugdunensis HKU09-01]
ATGATTAGACGCGGCGATGTATATTTAGCTGATTTATCACCGGTACAAGGGTCTGAACAAGGGGGAGTAAGACCAGTTGT
CATCATTCAAAATGACACCGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCAATTACTGGAAGGATTAATAAAGCGA
AAATACCCACTCATGTGGAAATAGGTAAAAAGAAATATAAGTTAGATAAAGATTCTGTTATTCTGCTAGAGCAAATACGA
ACATTAGATAAAAAAAGATTAAAAGAAAAACTTACTTATCTCTCTGAGGATAAAATGAAAGAAGTAGATCATGCCCTAGA
CATTAGTCTAGGTTTACATAACTATCATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.92 Da        Isoelectric Point: 4.0115

>AT24587 WP_002461193.1 NC_013893:1005015-1005185 [Staphylococcus lugdunensis HKU09-01]
MLTFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNHQSE

Download         Length: 171 bp

>AT24587 NC_013893:1005015-1005185 [Staphylococcus lugdunensis HKU09-01]
ATGCTAACTTTTAATCAAAATCGTAGTCATAGTCTAGAACAGTCATTAAAAGAAGGGTATGCTCAGATGGCAGACCTTAA
TCTCTCCCTAGCAACAGAGGCTTTCCCAATTGAATGTGAAGCTTGTGATTGCAATGAAACTTATCTAACTTCCAATCATC
AGAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3R6

Antitoxin

Source ID Structure
AlphaFold DB A0A853V233

References