Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 19017..19660 Replicon plasmid unnamed4
Accession NZ_CP097674
Organism Klebsiella pneumoniae strain IR5077_1

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag M3X94_RS29320 Protein ID WP_001044770.1
Coordinates 19017..19433 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag M3X94_RS29325 Protein ID WP_001261282.1
Coordinates 19430..19660 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X94_RS29300 (M3X94_29300) 15120..15392 - 273 Protein_22 transposase -
M3X94_RS29310 (M3X94_29310) 16374..17396 - 1023 WP_000361404.1 helicase UvrD -
M3X94_RS29315 (M3X94_29315) 17381..18943 - 1563 WP_004206609.1 AAA family ATPase -
M3X94_RS29320 (M3X94_29320) 19017..19433 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
M3X94_RS29325 (M3X94_29325) 19430..19660 - 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M3X94_RS29330 (M3X94_29330) 19617..20078 + 462 WP_014343465.1 hypothetical protein -
M3X94_RS29335 (M3X94_29335) 20239..21183 + 945 WP_011977810.1 hypothetical protein -
M3X94_RS29340 (M3X94_29340) 21220..21612 + 393 WP_011977811.1 hypothetical protein -
M3X94_RS29345 (M3X94_29345) 21670..22191 + 522 WP_013214008.1 hypothetical protein -
M3X94_RS29350 (M3X94_29350) 22237..22440 + 204 WP_011977813.1 hypothetical protein -
M3X94_RS29355 (M3X94_29355) 22470..23474 + 1005 WP_011977814.1 hypothetical protein -
M3X94_RS29360 (M3X94_29360) 23658..24437 + 780 WP_013214009.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaKPC-2 - 1..92812 92812


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T245860 WP_001044770.1 NZ_CP097674:c19433-19017 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT245860 WP_001261282.1 NZ_CP097674:c19660-19430 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References