Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 13895..14631 Replicon plasmid unnamed3
Accession NZ_CP097673
Organism Klebsiella pneumoniae strain IR5077_1

Toxin (Protein)


Gene name tacT Uniprot ID A0A2J5Q928
Locus tag M3X94_RS27620 Protein ID WP_004098919.1
Coordinates 14149..14631 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A7D3T1D0
Locus tag M3X94_RS27615 Protein ID WP_004213599.1
Coordinates 13895..14161 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X94_RS27595 (11408) 11408..12412 + 1005 WP_000427619.1 IS110-like element IS5075 family transposase -
M3X94_RS27600 (12698) 12698..13192 + 495 WP_004213594.1 hypothetical protein -
M3X94_RS27605 (13253) 13253..13456 + 204 WP_004213596.1 HHA domain-containing protein -
M3X94_RS27610 (13470) 13470..13700 + 231 WP_004213598.1 hypothetical protein -
M3X94_RS27615 (13895) 13895..14161 + 267 WP_004213599.1 DUF1778 domain-containing protein Antitoxin
M3X94_RS27620 (14149) 14149..14631 + 483 WP_004098919.1 GNAT family N-acetyltransferase Toxin
M3X94_RS27625 (15052) 15052..16279 + 1228 Protein_19 IS3 family transposase -
M3X94_RS27630 (16275) 16275..16670 - 396 Protein_20 IS3 family transposase -
M3X94_RS27635 (16845) 16845..17867 - 1023 WP_004214536.1 porphobilinogen synthase -
M3X94_RS27640 (17864) 17864..18901 - 1038 WP_226321664.1 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaSHV-12 / blaCTX-M-65 / fosA3 / blaTEM-1B / rmtB rmpA2 / rmpA / iutA / iucD / iucC / iucB / iucA 1..292919 292919
- inside IScluster/Tn blaSHV-12 - 126..16279 16153


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17335.06 Da        Isoelectric Point: 10.0704

>T245852 WP_004098919.1 NZ_CP097673:14149-14631 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKKVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10151.58 Da        Isoelectric Point: 4.5141

>AT245852 WP_004213599.1 NZ_CP097673:13895-14161 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRVLIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDDSAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J5Q928

Antitoxin

Source ID Structure
AlphaFold DB A0A7D3T1D0

References