Detailed information of TA system TA024585

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 4193138..4193754
• Replicon: chromosome
• Accession: NC_013892
• Organism: Xenorhabdus bovienii SS-2004

Toxin (Protein)

• Gene name: doc
• Uniprot ID: N1NJJ4
• Locus tag: XBJ1_RS18765
• Protein ID: WP_010847655.1
• Coordinates: 4193356..4193754 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: D3V753
• Locus tag: XBJ1_RS18760
• Protein ID: WP_012990615.1
• Coordinates: 4193138..4193359 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XBJ1_RS18745	4188574..4189086	+	513	WP_038199639.1	host cell division inhibitor Icd-like protein	-
XBJ1_RS18750	4189089..4189307	+	219	WP_012990611.1	hypothetical protein	-
XBJ1_RS18755	4189307..4192021	+	2715	WP_012990612.1	TOPRIM and DUF927 domain-containing protein	-
XBJ1_RS20370	4192313..4192525	+	213	WP_012990613.1	ogr/Delta-like zinc finger family protein	-
XBJ1_RS18760	4193138..4193359	+	222	WP_012990615.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
XBJ1_RS18765	4193356..4193754	+	399	WP_010847655.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
XBJ1_RS21835	4194252..4194416	+	165	WP_012990616.1	hypothetical protein	-
XBJ1_RS18775	4194644..4195468	+	825	WP_012990617.1	DNA damage-inducible protein D	-
XBJ1_RS18780	4195823..4196212	+	390	Protein_3750	DUF4102 domain-containing protein	-
XBJ1_RS18785	4196343..4196564	+	222	WP_012990619.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
XBJ1_RS18790	4196712..4198124	-	1413	WP_012990620.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4179285..4196564	17279

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (5-120)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-53)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14957.88 Da
• Isoelectric Point: 6.0764

>T24585 WP_010847655.1 NC_013892:4193356-4193754 [Xenorhabdus bovienii SS-2004]
MIWVSAQEVIAFHDRILQRLPGVAGMPDSGRAEALIYRVQNRTHYEGITDIFELAATYWAAIARGHIFNDGNKRTAFFVT
MTFLYRNGIKIRDNDNTLENLTVDAATGEKTVDQLAQHLRELVDYTNPSCNP

Nucleotide

• Length: 399 bp

>T24585 NC_013892:4193356-4193754 [Xenorhabdus bovienii SS-2004]
ATGATATGGGTCAGCGCACAGGAAGTTATCGCTTTTCATGACCGAATATTACAACGGCTTCCCGGCGTTGCCGGAATGCC
CGATTCTGGTAGAGCTGAAGCGCTCATCTATCGGGTACAAAACCGTACACACTATGAAGGCATAACAGATATTTTTGAAC
TTGCAGCGACCTATTGGGCTGCTATCGCTCGTGGTCATATTTTCAATGATGGTAATAAGCGCACAGCGTTTTTCGTTACC
ATGACTTTTCTCTATCGTAATGGTATCAAGATCCGTGATAACGACAATACATTGGAAAACTTAACAGTAGATGCCGCTAC
GGGCGAGAAAACCGTTGACCAGTTGGCGCAGCACCTGCGCGAATTGGTGGACTATACTAACCCGAGCTGTAATCCATGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8128.96 Da
• Isoelectric Point: 5.5589

>AT24585 WP_012990615.1 NC_013892:4193138-4193359 [Xenorhabdus bovienii SS-2004]
MRTYTSTQARANIAEVLDTAAHGEPVEITRRDGSSAVVISRAEFDAWQNAKLDAEFDSIMQRHGHTIEALTNR

Nucleotide

• Length: 222 bp

>AT24585 NC_013892:4193138-4193359 [Xenorhabdus bovienii SS-2004]
ATGCGTACATACACCTCAACTCAAGCCCGTGCCAACATCGCGGAAGTGTTGGACACAGCGGCTCACGGTGAACCTGTTGA
AATCACTCGTCGAGACGGTAGTTCAGCGGTCGTTATCAGTAGAGCTGAATTCGATGCTTGGCAAAACGCTAAGCTGGATG
CAGAGTTCGATTCGATTATGCAACGTCATGGGCATACGATAGAGGCACTGACAAATCGATGA

Structures

Toxin

• AlphaFold DB: N1NJJ4

Antitoxin

• AlphaFold DB: D3V753