Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 3032256..3032764 Replicon chromosome
Accession NC_013892
Organism Xenorhabdus bovienii SS-2004

Toxin (Protein)


Gene name relE Uniprot ID D3V8N9
Locus tag XBJ1_RS13005 Protein ID WP_012989464.1
Coordinates 3032510..3032764 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID D3V8N8
Locus tag XBJ1_RS13000 Protein ID WP_012989463.1
Coordinates 3032256..3032510 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XBJ1_RS12970 3027555..3028886 - 1332 WP_012989458.1 murein transglycosylase D -
XBJ1_RS12975 3028959..3029714 - 756 WP_012989459.1 hydroxyacylglutathione hydrolase -
XBJ1_RS12980 3029755..3030471 + 717 WP_012989460.1 methyltransferase domain-containing protein -
XBJ1_RS12985 3030529..3030999 - 471 WP_012989461.1 ribonuclease HI -
XBJ1_RS12990 3031063..3031812 + 750 WP_012989462.1 DNA polymerase III subunit epsilon -
XBJ1_RS13000 3032256..3032510 + 255 WP_012989463.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
XBJ1_RS13005 3032510..3032764 + 255 WP_012989464.1 Txe/YoeB family addiction module toxin Toxin
XBJ1_RS13010 3032821..3033366 - 546 WP_012989465.1 GNAT family N-acetyltransferase -
XBJ1_RS13015 3033764..3035758 + 1995 WP_012989466.1 transketolase -
XBJ1_RS13020 3036035..3037054 + 1020 WP_012989467.1 erythrose-4-phosphate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3026655..3027542 887


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10190.74 Da        Isoelectric Point: 8.0123

>T24584 WP_012989464.1 NC_013892:3032510-3032764 [Xenorhabdus bovienii SS-2004]
MKITFSDSAWEDYLYWQQTDKAILKRINQLIKDIRRQPFEGIGKPEPLKHNLSGFWSRRITEEHRLIYAIEEDQIMIAAC
RYLY

Download         Length: 255 bp

>T24584 NC_013892:3032510-3032764 [Xenorhabdus bovienii SS-2004]
ATGAAAATTACTTTTTCCGACAGTGCCTGGGAAGATTATCTTTACTGGCAACAAACAGATAAGGCAATACTGAAACGCAT
TAATCAACTCATTAAAGATATACGTCGGCAGCCTTTTGAAGGGATTGGTAAACCAGAACCTTTAAAACATAACTTGTCAG
GGTTCTGGTCAAGGCGTATCACTGAGGAACACCGTTTGATATATGCTATTGAAGAAGATCAAATAATGATAGCAGCCTGT
CGTTATCTTTATTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9358.69 Da        Isoelectric Point: 4.7404

>AT24584 WP_012989463.1 NC_013892:3032256-3032510 [Xenorhabdus bovienii SS-2004]
MKVLTYSEARQNLSETMISVVNDCSPAIITRKNGESCVLMSLSDYESLQETAYLMRSPNNVNRLMDSIAELRAGKGKAKE
LDLD

Download         Length: 255 bp

>AT24584 NC_013892:3032256-3032510 [Xenorhabdus bovienii SS-2004]
ATGAAAGTCTTAACATATAGCGAAGCTAGACAGAATCTTTCTGAAACCATGATTAGCGTGGTCAACGATTGCAGCCCCGC
CATTATTACCCGAAAAAACGGTGAAAGTTGTGTGTTGATGTCTTTGTCTGATTATGAATCCTTACAGGAAACTGCATACT
TGATGCGTTCTCCAAACAATGTGAATCGTCTAATGGACTCAATTGCAGAATTGAGAGCAGGAAAGGGTAAGGCTAAAGAG
TTGGATTTAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3V8N9

Antitoxin

Source ID Structure
AlphaFold DB A0A077Q7L4

References