Detailed information of TA system TA024583

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2757834..2758465
• Replicon: chromosome
• Accession: NC_013892
• Organism: Xenorhabdus bovienii SS-2004

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: XBJ1_RS11805
• Protein ID: WP_173346397.1
• Coordinates: 2757834..2758112 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: D3V7V6
• Locus tag: XBJ1_RS11810
• Protein ID: WP_012989201.1
• Coordinates: 2758109..2758465 (+)
• Length: 119 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XBJ1_RS11780	2753275..2753931	+	657	Protein_2384	IS4 family transposase	-
XBJ1_RS11795	2755369..2756007	+	639	Protein_2386	transposase	-
XBJ1_RS11800	2756188..2756952	-	765	WP_012989197.1	hypothetical protein	-
XBJ1_RS11805	2757834..2758112	+	279	WP_173346397.1	type II toxin-antitoxin system HicA family toxin	Toxin
XBJ1_RS11810	2758109..2758465	+	357	WP_012989201.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
XBJ1_RS22100	2758976..2759230	-	255	Protein_2390	lysis protein	-
XBJ1_RS22105	2759234..2759638	-	405	Protein_2391	lysozyme	-
XBJ1_RS11825	2759653..2760633	+	981	WP_012989205.1	tyrosine-type recombinase/integrase	-
XBJ1_RS11830	2762156..2763193	+	1038	WP_041573280.1	IS630 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2743923..2789068	45145

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (30-80)

Antitoxin

• Uncharacterised protein family HicB (59-111)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10144.61 Da
• Isoelectric Point: 10.6521

>T24583 WP_173346397.1 NC_013892:2757834-2758112 [Xenorhabdus bovienii SS-2004]
MNKQISALRTRQQRTLEQIFKTPVSSGIKWSDIESLIKALGGEIKEGRGSRCKFLLNGSIANFHRPHPSPDTDKGAVAGL
REWLESIGVTPS

Nucleotide

• Length: 279 bp

>T24583 NC_013892:2757834-2758112 [Xenorhabdus bovienii SS-2004]
ATGAACAAACAGATTTCCGCGCTCCGAACGAGGCAACAACGTACCTTAGAACAAATTTTTAAAACGCCGGTATCGTCGGG
AATTAAATGGTCAGATATTGAATCGTTAATCAAGGCATTGGGCGGTGAAATCAAGGAAGGTCGGGGTTCGCGTTGTAAAT
TTTTGCTGAATGGGAGTATTGCCAATTTTCATCGCCCCCATCCGTCACCCGACACAGACAAAGGGGCTGTGGCGGGATTA
CGGGAATGGTTGGAAAGTATAGGAGTCACACCATCATGA

Antitoxin

Protein

• Length: 119 a.a.
• Molecular weight: 13304.11 Da
• Isoelectric Point: 6.2268

>AT24583 WP_012989201.1 NC_013892:2758109-2758465 [Xenorhabdus bovienii SS-2004]
MSKQNTNIMEIAGLSAVISYVPELGMFRGKFLGLSGYCDFVADSIAGLHAEGRLSLNEYLEDCRSANIEPYQKREKTKTF
TLRYPESFGERLNQAATEHHISVNAFILETLGERLRNI

Nucleotide

• Length: 357 bp

>AT24583 NC_013892:2758109-2758465 [Xenorhabdus bovienii SS-2004]
ATGAGTAAGCAAAATACGAATATTATGGAGATCGCCGGACTCTCGGCGGTGATTAGTTATGTCCCTGAACTCGGTATGTT
TCGGGGGAAGTTTTTAGGGTTATCCGGTTATTGTGATTTTGTGGCTGACAGTATTGCTGGGCTGCATGCTGAAGGACGAT
TGTCTTTGAATGAATATCTAGAAGACTGCCGTTCCGCCAATATCGAGCCTTATCAGAAACGTGAAAAAACAAAAACGTTT
ACTTTACGTTATCCCGAATCGTTTGGCGAACGGTTAAATCAGGCTGCAACCGAACACCATATTTCGGTCAACGCGTTCAT
TTTGGAGACATTGGGTGAGCGCCTGAGAAACATCTAA

Structures

Antitoxin

• AlphaFold DB: D3V7V6