Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 27337..27862 Replicon plasmid unnamed3
Accession NZ_CP097666
Organism Klebsiella pneumoniae strain IR1230_1

Toxin (Protein)


Gene name ccdB Uniprot ID V0SSI5
Locus tag M3X90_RS27490 Protein ID WP_001159868.1
Coordinates 27557..27862 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1PPD8
Locus tag M3X90_RS27485 Protein ID WP_000813634.1
Coordinates 27337..27555 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X90_RS27460 (23399) 23399..24532 + 1134 WP_000545983.1 DUF3800 domain-containing protein -
M3X90_RS27465 (24552) 24552..24836 + 285 WP_000642771.1 hypothetical protein -
M3X90_RS27470 (25007) 25007..25654 - 648 WP_000074712.1 hypothetical protein -
M3X90_RS27475 (25642) 25642..25977 - 336 WP_000628093.1 hypothetical protein -
M3X90_RS27480 (26157) 26157..26738 - 582 WP_000139427.1 hypothetical protein -
M3X90_RS27485 (27337) 27337..27555 + 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
M3X90_RS27490 (27557) 27557..27862 + 306 WP_001159868.1 type II toxin-antitoxin system toxin CcdB Toxin
M3X90_RS27495 (27863) 27863..28669 + 807 WP_249246927.1 site-specific integrase -
M3X90_RS27500 (28727) 28727..28984 - 258 WP_000764642.1 hypothetical protein -
M3X90_RS27505 (29113) 29113..29217 - 105 WP_032409716.1 hypothetical protein -
M3X90_RS27510 (29447) 29447..29635 + 189 WP_000957857.1 hypothetical protein -
M3X90_RS27515 (29645) 29645..30844 + 1200 WP_064765287.1 IS91 family transposase -
M3X90_RS27520 (31014) 31014..31850 - 837 Protein_41 ParB/RepB/Spo0J family partition protein -
M3X90_RS27525 (31920) 31920..32168 - 249 WP_001568055.1 DUF905 domain-containing protein -
M3X90_RS27530 (32217) 32217..32759 - 543 WP_014343512.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaCTX-M-55 / mph(A) / sul1 / dfrA25 / blaKPC-2 / aac(3)-IId / sul2 / aph(3'')-Ib / aph(6)-Id - 1..147295 147295
- flank IS/Tn - - 22206..22910 704
- flank IS/Tn - - 29645..30844 1199


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11706.51 Da        Isoelectric Point: 6.4674

>T245825 WP_001159868.1 NZ_CP097666:27557-27862 [Klebsiella pneumoniae]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8372.34 Da        Isoelectric Point: 4.7405

>AT245825 WP_000813634.1 NZ_CP097666:27337-27555 [Klebsiella pneumoniae]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4VUB
PDB 2VUB
PDB 7EPI
PDB 7EPG
PDB 3VUB
PDB 1X75
PDB 1VUB
PDB 7EPJ
PDB 3HPW
PDB 3G7Z

Antitoxin

Source ID Structure
PDB 3TCJ
PDB 2H3A
PDB 2ADN
PDB 2ADL
PDB 3HPW
PDB 2H3C
PDB 3G7Z
AlphaFold DB A0A829CQY2

References