Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 903..1639 Replicon plasmid unnamed2
Accession NZ_CP097665
Organism Klebsiella pneumoniae strain IR1230_1

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag M3X90_RS26470 Protein ID WP_114473045.1
Coordinates 903..1385 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag M3X90_RS26475 Protein ID WP_003026799.1
Coordinates 1373..1639 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X90_RS26470 (M3X90_26470) 903..1385 - 483 WP_114473045.1 GNAT family N-acetyltransferase Toxin
M3X90_RS26475 (M3X90_26475) 1373..1639 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
M3X90_RS26480 (M3X90_26480) 1767..2165 + 399 WP_250203212.1 hypothetical protein -
M3X90_RS26485 (M3X90_26485) 2961..3248 + 288 WP_114473050.1 chorismate mutase -
M3X90_RS26490 (M3X90_26490) 3205..3297 - 93 Protein_5 hypothetical protein -
M3X90_RS26495 (M3X90_26495) 3255..3357 - 103 Protein_6 Hok/Gef family protein -
M3X90_RS26500 (M3X90_26500) 3408..4440 - 1033 Protein_7 GlxA family transcriptional regulator -
M3X90_RS26505 (M3X90_26505) 4682..6133 + 1452 WP_114473044.1 L-tyrosine/L-tryptophan isonitrile synthase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..146332 146332


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17298.01 Da        Isoelectric Point: 9.5893

>T245822 WP_114473045.1 NZ_CP097665:c1385-903 [Klebsiella pneumoniae]
VGCITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDISLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFKASQTHKRTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT245822 WP_003026799.1 NZ_CP097665:c1639-1373 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References