Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4796415..4796931 Replicon chromosome
Accession NZ_CP097663
Organism Klebsiella pneumoniae strain IR1230_1

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag M3X90_RS23735 Protein ID WP_002886902.1
Coordinates 4796415..4796699 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M3X90_RS23740 Protein ID WP_002886901.1
Coordinates 4796689..4796931 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X90_RS23710 (M3X90_23710) 4791899..4792162 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
M3X90_RS23715 (M3X90_23715) 4792292..4792465 + 174 WP_002886906.1 hypothetical protein -
M3X90_RS23720 (M3X90_23720) 4792468..4793211 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M3X90_RS23725 (M3X90_23725) 4793568..4795706 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
M3X90_RS23730 (M3X90_23730) 4795947..4796411 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M3X90_RS23735 (M3X90_23735) 4796415..4796699 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M3X90_RS23740 (M3X90_23740) 4796689..4796931 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M3X90_RS23745 (M3X90_23745) 4797009..4798919 - 1911 WP_004152270.1 PRD domain-containing protein -
M3X90_RS23750 (M3X90_23750) 4798942..4800096 - 1155 WP_002886900.1 lactonase family protein -
M3X90_RS23755 (M3X90_23755) 4800162..4800902 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T245820 WP_002886902.1 NZ_CP097663:c4796699-4796415 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT245820 WP_002886901.1 NZ_CP097663:c4796931-4796689 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References