Detailed information of TA system TA024582

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1584920..1585540
• Replicon: chromosome
• Accession: NC_013892
• Organism: Xenorhabdus bovienii SS-2004

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: N1NUC1
• Locus tag: XBJ1_RS06965
• Protein ID: WP_010845060.1
• Coordinates: 1585337..1585540 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: XBJ1_RS06960
• Protein ID: WP_038198607.1
• Coordinates: 1584920..1585288 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XBJ1_RS06950	1579950..1581149	+	1200	WP_012988120.1	efflux RND transporter periplasmic adaptor subunit	-
XBJ1_RS06955	1581165..1584314	+	3150	WP_012988121.1	multidrug efflux RND transporter permease subunit	-
XBJ1_RS06960	1584920..1585288	+	369	WP_038198607.1	Hha toxicity modulator TomB	Antitoxin
XBJ1_RS06965	1585337..1585540	+	204	WP_010845060.1	hemolysin expression modulator Hha	Toxin
XBJ1_RS06970	1586594..1587886	-	1293	WP_012988124.1	ammonium transporter AmtB	-
XBJ1_RS06975	1587902..1588240	-	339	WP_038198610.1	P-II family nitrogen regulator	-
XBJ1_RS06980	1588408..1590177	-	1770	WP_143827722.1	SmdB family multidrug efflux ABC transporter permease/ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-114)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8077.34 Da
• Isoelectric Point: 6.9770

>T24582 WP_010845060.1 NC_013892:1585337-1585540 [Xenorhabdus bovienii SS-2004]
MTKTDYLMRLRKCTSIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Nucleotide

• Length: 204 bp

>T24582 NC_013892:1585337-1585540 [Xenorhabdus bovienii SS-2004]
ATGACTAAAACTGACTATCTGATGCGTTTGAGAAAATGCACTTCTATTGAAACACTGGAACGTGTAATTGAAAAAAATAA
ATATGAGCTTTCGGATGATGAACTTGAATTGTTCTACTCTGCTGCTGACCACCGCTTAGCTGAACTTACTATGAATAAGC
TTTATGATAAGATCCCATCATCTGTTTGGAAATTTGTCCGCTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14440.36 Da
• Isoelectric Point: 5.5225

>AT24582 WP_038198607.1 NC_013892:1584920-1585288 [Xenorhabdus bovienii SS-2004]
MDEYSPRRHDIVELKYLCENLIHEAFSVLNRADNHWINDLTSEKSLKLNELIEHIAAFVWSFKIKYADNYNLSTLIDKYL
DETYNLFGSDKISCFELTKWQKTNEHLTNILLHDLNACLSKT

Nucleotide

• Length: 369 bp

>AT24582 NC_013892:1584920-1585288 [Xenorhabdus bovienii SS-2004]
ATGGATGAATATTCACCAAGAAGACATGATATTGTTGAATTAAAATACTTATGTGAAAATTTAATTCACGAGGCATTTTC
AGTGCTAAATCGCGCTGATAATCATTGGATTAACGATCTGACTTCCGAAAAAAGCTTAAAACTAAATGAATTGATCGAGC
ACATTGCAGCGTTCGTCTGGAGTTTTAAAATTAAATACGCAGATAACTACAATCTCAGTACCTTAATTGATAAATACCTG
GATGAAACATATAATTTGTTCGGGAGTGATAAGATAAGCTGTTTTGAACTTACAAAATGGCAAAAAACAAACGAACACTT
AACTAACATTCTGTTGCATGATTTGAATGCCTGTTTAAGCAAAACCTGA

Structures

Toxin

• AlphaFold DB: N1NUC1