Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 876424..877081 Replicon chromosome
Accession NZ_CP097663
Organism Klebsiella pneumoniae strain IR1230_1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag M3X90_RS04435 Protein ID WP_002916310.1
Coordinates 876671..877081 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M3X90_RS04430 Protein ID WP_002916312.1
Coordinates 876424..876690 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X90_RS04405 (M3X90_04405) 871580..873013 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
M3X90_RS04410 (M3X90_04410) 873132..873860 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M3X90_RS04415 (M3X90_04415) 873910..874221 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
M3X90_RS04420 (M3X90_04420) 874385..875044 + 660 WP_002916317.1 hemolysin III family protein -
M3X90_RS04425 (M3X90_04425) 875195..876178 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
M3X90_RS04430 (M3X90_04430) 876424..876690 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M3X90_RS04435 (M3X90_04435) 876671..877081 + 411 WP_002916310.1 protein YgfX Toxin
M3X90_RS04440 (M3X90_04440) 877088..877609 - 522 WP_002916308.1 flavodoxin FldB -
M3X90_RS04445 (M3X90_04445) 877710..878606 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M3X90_RS04450 (M3X90_04450) 878629..879342 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M3X90_RS04455 (M3X90_04455) 879348..881081 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T245812 WP_002916310.1 NZ_CP097663:876671-877081 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT245812 WP_002916312.1 NZ_CP097663:876424-876690 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References