Detailed information of TA system TA024581

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 1272150..1272732
• Replicon: chromosome
• Accession: NC_013892
• Organism: Xenorhabdus bovienii SS-2004

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: D3UXP8
• Locus tag: XBJ1_RS05595
• Protein ID: WP_012987830.1
• Coordinates: 1272150..1272446 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: XBJ1_RS05600
• Protein ID: WP_012987831.1
• Coordinates: 1272448..1272732 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XBJ1_RS05565	1268229..1268774	+	546	WP_012987824.1	SLATT domain-containing protein	-
XBJ1_RS05570	1268752..1270122	+	1371	WP_038198469.1	reverse transcriptase	-
XBJ1_RS05575	1270340..1270765	-	426	WP_012987825.1	type II toxin-antitoxin system VapC family toxin	-
XBJ1_RS05580	1270765..1271019	-	255	WP_012987826.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
XBJ1_RS05585	1271241..1271570	+	330	WP_012987828.1	type I toxin-antitoxin system SymE family toxin	-
XBJ1_RS05590	1271710..1272048	+	339	WP_012987829.1	SymE family type I addiction module toxin	-
XBJ1_RS05595	1272150..1272446	+	297	WP_012987830.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
XBJ1_RS05600	1272448..1272732	+	285	WP_012987831.1	putative addiction module antidote protein	Antitoxin
XBJ1_RS05605	1272818..1273201	-	384	WP_012987832.1	hypothetical protein	-
XBJ1_RS05610	1273943..1274257	-	315	WP_012987834.1	hypothetical protein	-
XBJ1_RS05615	1274405..1274827	-	423	WP_012987835.1	hypothetical protein	-
XBJ1_RS19000	1274824..1275513	-	690	WP_012987836.1	RHS repeat-associated core domain-containing protein	-
XBJ1_RS05625	1275592..1275801	-	210	WP_012987837.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1137911..1304106	166195

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (47-89)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11271.07 Da
• Isoelectric Point: 9.4872

>T24581 WP_012987830.1 NC_013892:1272150-1272446 [Xenorhabdus bovienii SS-2004]
MITIERTQDFEKWLKSLKDRIAKAKILIRIERMEEGNFGDVEPVGAGVLELRIHYGQGYRVYFANKNNEIILLLCGGDKS
SQQADIKKAKQLAKEWGF

Nucleotide

• Length: 297 bp

>T24581 NC_013892:1272150-1272446 [Xenorhabdus bovienii SS-2004]
ATGATAACCATTGAAAGGACGCAAGATTTTGAAAAATGGTTAAAATCCTTAAAAGACAGGATAGCAAAAGCCAAAATCTT
AATCAGAATTGAAAGAATGGAAGAGGGGAATTTTGGCGATGTTGAACCTGTGGGAGCCGGGGTTTTGGAACTTAGAATAC
ATTACGGGCAAGGCTATCGTGTCTACTTTGCTAACAAAAATAATGAAATCATATTATTACTCTGTGGTGGAGATAAAAGC
AGCCAGCAGGCAGATATAAAGAAAGCAAAGCAACTTGCGAAAGAATGGGGATTTTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10544.02 Da
• Isoelectric Point: 8.4051

>AT24581 WP_012987831.1 NC_013892:1272448-1272732 [Xenorhabdus bovienii SS-2004]
MKTEPKKFDVVEFLETEEDIQAYLNAAIEENDTKYLFKALGNIARRKNISQLSKESGISREGIYKALSGEGNPSFNTVYK
ISKVLGLKLHFTGA

Nucleotide

• Length: 285 bp

>AT24581 NC_013892:1272448-1272732 [Xenorhabdus bovienii SS-2004]
ATGAAAACAGAACCAAAAAAATTTGATGTTGTGGAGTTTTTAGAAACGGAAGAAGATATTCAGGCCTACTTAAATGCGGC
TATCGAAGAGAATGATACAAAATATTTATTTAAAGCATTAGGCAACATAGCCAGAAGAAAAAATATCAGTCAACTCTCGA
AAGAATCAGGAATAAGCCGTGAAGGGATATACAAGGCGTTATCCGGTGAAGGCAACCCCTCGTTTAATACGGTATACAAA
ATATCAAAAGTACTGGGTTTGAAACTGCATTTCACAGGAGCTTAA

Structures

Toxin

• AlphaFold DB: D3UXP8