Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1272150..1272732 Replicon chromosome
Accession NC_013892
Organism Xenorhabdus bovienii SS-2004

Toxin (Protein)


Gene name PumA Uniprot ID D3UXP8
Locus tag XBJ1_RS05595 Protein ID WP_012987830.1
Coordinates 1272150..1272446 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag XBJ1_RS05600 Protein ID WP_012987831.1
Coordinates 1272448..1272732 (+) Length 95 a.a.

Genomic Context

XBJ1_RS05565XBJ1_RS05570XBJ1_RS05585XBJ1_RS05590XBJ1_RS05595XBJ1_RS05600XBJ1_RS05575XBJ1_RS05580XBJ1_RS05605XBJ1_RS05610XBJ1_RS05615XBJ1_RS19000XBJ1_RS05625
Location: 1268229..1268774 (546 bp)
Type: Others
Protein ID: WP_012987824.1
Location: 1268752..1270122 (1371 bp)
Type: Others
Protein ID: WP_038198469.1
Location: 1271241..1271570 (330 bp)
Type: Others
Protein ID: WP_012987828.1
Location: 1271710..1272048 (339 bp)
Type: Others
Protein ID: WP_012987829.1
Location: 1272150..1272446 (297 bp)
Type: Toxin
Protein ID: WP_012987830.1
Location: 1272448..1272732 (285 bp)
Type: Antitoxin
Protein ID: WP_012987831.1
Location: 1270340..1270765 (426 bp)
Type: Others
Protein ID: WP_012987825.1
Location: 1270765..1271019 (255 bp)
Type: Others
Protein ID: WP_012987826.1
Location: 1272818..1273201 (384 bp)
Type: Others
Protein ID: WP_012987832.1
Location: 1273943..1274257 (315 bp)
Type: Others
Protein ID: WP_012987834.1
Location: 1274405..1274827 (423 bp)
Type: Others
Protein ID: WP_012987835.1
Location: 1274824..1275513 (690 bp)
Type: Others
Protein ID: WP_012987836.1
Location: 1275592..1275801 (210 bp)
Type: Others
Protein ID: WP_012987837.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
XBJ1_RS055651268229..1268774+546WP_012987824.1SLATT domain-containing protein-
XBJ1_RS055701268752..1270122+1371WP_038198469.1reverse transcriptase-
XBJ1_RS055751270340..1270765-426WP_012987825.1type II toxin-antitoxin system VapC family toxin-
XBJ1_RS055801270765..1271019-255WP_012987826.1type II toxin-antitoxin system Phd/YefM family antitoxin-
XBJ1_RS055851271241..1271570+330WP_012987828.1type I toxin-antitoxin system SymE family toxin-
XBJ1_RS055901271710..1272048+339WP_012987829.1SymE family type I addiction module toxin-
XBJ1_RS055951272150..1272446+297WP_012987830.1type II toxin-antitoxin system RelE/ParE family toxinToxin
XBJ1_RS056001272448..1272732+285WP_012987831.1putative addiction module antidote proteinAntitoxin
XBJ1_RS056051272818..1273201-384WP_012987832.1hypothetical protein-
XBJ1_RS056101273943..1274257-315WP_012987834.1hypothetical protein-
XBJ1_RS056151274405..1274827-423WP_012987835.1hypothetical protein-
XBJ1_RS190001274824..1275513-690WP_012987836.1RHS repeat-associated core domain-containing protein-
XBJ1_RS056251275592..1275801-210WP_012987837.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1137911..1304106166195


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-89)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11271.07 Da        Isoelectric Point: 9.4872

>T24581 WP_012987830.1 NC_013892:1272150-1272446 [Xenorhabdus bovienii SS-2004]
MITIERTQDFEKWLKSLKDRIAKAKILIRIERMEEGNFGDVEPVGAGVLELRIHYGQGYRVYFANKNNEIILLLCGGDKS
SQQADIKKAKQLAKEWGF

Download         Length: 297 bp

>T24581 NC_013892:1272150-1272446 [Xenorhabdus bovienii SS-2004]
ATGATAACCATTGAAAGGACGCAAGATTTTGAAAAATGGTTAAAATCCTTAAAAGACAGGATAGCAAAAGCCAAAATCTT
AATCAGAATTGAAAGAATGGAAGAGGGGAATTTTGGCGATGTTGAACCTGTGGGAGCCGGGGTTTTGGAACTTAGAATAC
ATTACGGGCAAGGCTATCGTGTCTACTTTGCTAACAAAAATAATGAAATCATATTATTACTCTGTGGTGGAGATAAAAGC
AGCCAGCAGGCAGATATAAAGAAAGCAAAGCAACTTGCGAAAGAATGGGGATTTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10544.02 Da        Isoelectric Point: 8.4051

>AT24581 WP_012987831.1 NC_013892:1272448-1272732 [Xenorhabdus bovienii SS-2004]
MKTEPKKFDVVEFLETEEDIQAYLNAAIEENDTKYLFKALGNIARRKNISQLSKESGISREGIYKALSGEGNPSFNTVYK
ISKVLGLKLHFTGA

Download         Length: 285 bp

>AT24581 NC_013892:1272448-1272732 [Xenorhabdus bovienii SS-2004]
ATGAAAACAGAACCAAAAAAATTTGATGTTGTGGAGTTTTTAGAAACGGAAGAAGATATTCAGGCCTACTTAAATGCGGC
TATCGAAGAGAATGATACAAAATATTTATTTAAAGCATTAGGCAACATAGCCAGAAGAAAAAATATCAGTCAACTCTCGA
AAGAATCAGGAATAAGCCGTGAAGGGATATACAAGGCGTTATCCGGTGAAGGCAACCCCTCGTTTAATACGGTATACAAA
ATATCAAAAGTACTGGGTTTGAAACTGCATTTCACAGGAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBD3UXP8

Antitoxin

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Source
ID
Structure
No matching records found

References