Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5079851..5081532 Replicon chromosome
Accession NZ_CP097660
Organism Klebsiella pneumoniae strain IR12243_1

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag M3X86_RS25235 Protein ID WP_002885155.1
Coordinates 5079851..5080768 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag M3X86_RS25240 Protein ID WP_004151732.1
Coordinates 5080774..5081532 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X86_RS25215 (M3X86_25215) 5075157..5076677 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
M3X86_RS25220 (M3X86_25220) 5076674..5077672 + 999 WP_002885172.1 ribose ABC transporter permease -
M3X86_RS25225 (M3X86_25225) 5077703..5078644 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
M3X86_RS25230 (M3X86_25230) 5078719..5079726 + 1008 WP_004151731.1 carbohydrate kinase family protein -
M3X86_RS25235 (M3X86_25235) 5079851..5080768 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
M3X86_RS25240 (M3X86_25240) 5080774..5081532 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
M3X86_RS25245 (M3X86_25245) 5081618..5082346 - 729 WP_002885152.1 response regulator transcription factor -
M3X86_RS25250 (M3X86_25250) 5082619..5084766 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
M3X86_RS25255 (M3X86_25255) 5084996..5085682 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T245798 WP_002885155.1 NZ_CP097660:c5080768-5079851 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT245798 WP_004151732.1 NZ_CP097660:c5081532-5080774 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References