Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2744111..2745699 Replicon chromosome
Accession NZ_CP097660
Organism Klebsiella pneumoniae strain IR12243_1

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag M3X86_RS13615 Protein ID WP_004199851.1
Coordinates 2744111..2745433 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag M3X86_RS13620 Protein ID WP_002904790.1
Coordinates 2745433..2745699 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X86_RS13600 (M3X86_13600) 2739176..2741677 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
M3X86_RS13605 (M3X86_13605) 2741665..2742669 + 1005 WP_004199852.1 fimbrial protein -
M3X86_RS13610 (M3X86_13610) 2742802..2744094 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
M3X86_RS13615 (M3X86_13615) 2744111..2745433 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
M3X86_RS13620 (M3X86_13620) 2745433..2745699 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M3X86_RS13625 (M3X86_13625) 2745965..2746291 - 327 WP_002904788.1 hydroxyisourate hydrolase -
M3X86_RS13630 (M3X86_13630) 2746288..2746788 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M3X86_RS13635 (M3X86_13635) 2746766..2748145 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
M3X86_RS13640 (M3X86_13640) 2748491..2749645 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M3X86_RS13645 (M3X86_13645) 2749626..2750549 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T245794 WP_004199851.1 NZ_CP097660:c2745433-2744111 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT245794 WP_002904790.1 NZ_CP097660:c2745699-2745433 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References