Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 444732..445417 Replicon chromosome
Accession NC_013892
Organism Xenorhabdus bovienii SS-2004

Toxin (Protein)


Gene name mazF Uniprot ID D3UW81
Locus tag XBJ1_RS01935 Protein ID WP_012987047.1
Coordinates 444732..445070 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID D3UW83
Locus tag XBJ1_RS01940 Protein ID WP_012987048.1
Coordinates 445172..445417 (-) Length 82 a.a.

Genomic Context

XBJ1_RS01925XBJ1_RS01930XBJ1_RS20445XBJ1_RS01910XBJ1_RS01915XBJ1_RS01920XBJ1_RS01935XBJ1_RS01940XBJ1_RS01945XBJ1_RS01950
Location: 443490..444170 (681 bp)
Type: Others
Protein ID: WP_012987044.1
Location: 444167..444499 (333 bp)
Type: Others
Protein ID: WP_143827616.1
Location: 445422..445676 (255 bp)
Type: Others
Protein ID: WP_012987049.1
Location: 439927..440634 (708 bp)
Type: Others
Protein ID: WP_038198281.1
Location: 441079..442062 (984 bp)
Type: Others
Protein ID: WP_012987041.1
Location: 442204..442977 (774 bp)
Type: Others
Protein ID: WP_012987042.1
Location: 444732..445070 (339 bp)
Type: Toxin
Protein ID: WP_012987047.1
Location: 445172..445417 (246 bp)
Type: Antitoxin
Protein ID: WP_012987048.1
Location: 445760..448657 (2898 bp)
Type: Others
Protein ID: WP_012987050.1
Location: 448671..449135 (465 bp)
Type: Others
Protein ID: WP_012987051.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
XBJ1_RS01910439927..440634-708WP_038198281.1amino acid ABC transporter permease-
XBJ1_RS01915441079..442062-984WP_012987041.1IS30 family transposase-
XBJ1_RS01920442204..442977-774WP_012987042.1amino acid ABC transporter substrate-binding protein-
XBJ1_RS01925443490..444170+681WP_012987044.1AzlC family ABC transporter permease-
XBJ1_RS01930444167..444499+333WP_143827616.1AzlD domain-containing protein-
XBJ1_RS01935444732..445070-339WP_012987047.1endoribonuclease MazFToxin
XBJ1_RS01940445172..445417-246WP_012987048.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
XBJ1_RS20445445422..445676+255WP_012987049.1recombinase family protein-
XBJ1_RS01945445760..448657-2898WP_012987050.1valine--tRNA ligase-
XBJ1_RS01950448671..449135-465WP_012987051.1DNA polymerase III subunit chi-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--441079..442062983


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-109)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12111.05 Da        Isoelectric Point: 8.4866

>T24579 WP_012987047.1 NC_013892:c445070-444732 [Xenorhabdus bovienii SS-2004]
MKSKYVPEAGDIVWLDFDPQAGHEQAGHRPALVLSPAIYNGRIGLMLCCPMTTKIKGYPFEVKVEGEGEGDSAVLADQVK
SLDWRERNAKIKGKVSASVLSEVKAKAKALIG

Download         Length: 339 bp

>T24579 NC_013892:c445070-444732 [Xenorhabdus bovienii SS-2004]
ATGAAATCAAAATATGTACCAGAAGCTGGCGATATTGTATGGCTTGATTTTGATCCGCAAGCAGGGCACGAGCAAGCAGG
ACACCGCCCTGCATTGGTTCTTAGCCCTGCTATTTATAATGGTCGGATAGGGCTGATGTTATGTTGCCCCATGACCACTA
AGATCAAAGGCTATCCTTTTGAAGTAAAAGTAGAAGGTGAAGGTGAAGGGGATAGTGCAGTACTGGCTGATCAGGTAAAA
AGTTTAGACTGGCGCGAACGCAATGCTAAAATAAAAGGAAAAGTATCGGCTTCCGTACTTTCAGAGGTTAAAGCAAAAGC
TAAAGCGTTAATAGGCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8848.23 Da        Isoelectric Point: 5.0351

>AT24579 WP_012987048.1 NC_013892:c445417-445172 [Xenorhabdus bovienii SS-2004]
MSQVIVKKWGNSPSVRLPVSIMKAASLNVDDTVEITVEDGRIVIVPVRAKEYTLDALLSGVTNENIHEEISFGKPTGKEL
L

Download         Length: 246 bp

>AT24579 NC_013892:c445417-445172 [Xenorhabdus bovienii SS-2004]
ATGTCACAAGTTATCGTTAAAAAATGGGGTAATAGCCCGTCAGTAAGGCTTCCGGTTTCAATTATGAAAGCAGCGTCTCT
GAACGTCGATGATACTGTTGAAATTACTGTAGAAGATGGGCGTATCGTGATTGTACCTGTGCGCGCTAAAGAATATACGC
TTGATGCGTTACTTTCCGGTGTTACAAACGAAAATATTCATGAAGAAATTTCCTTCGGAAAACCAACTGGCAAGGAGCTA
CTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBD3UW81

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A077NCT9

References