Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 861518..862172 Replicon chromosome
Accession NZ_CP097660
Organism Klebsiella pneumoniae strain IR12243_1

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag M3X86_RS04355 Protein ID WP_004144731.1
Coordinates 861765..862172 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M3X86_RS04350 Protein ID WP_002916312.1
Coordinates 861518..861784 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X86_RS04325 (M3X86_04325) 856674..858107 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
M3X86_RS04330 (M3X86_04330) 858226..858954 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M3X86_RS04335 (M3X86_04335) 859004..859315 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
M3X86_RS04340 (M3X86_04340) 859479..860138 + 660 WP_002916317.1 hemolysin III family protein -
M3X86_RS04345 (M3X86_04345) 860289..861272 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
M3X86_RS04350 (M3X86_04350) 861518..861784 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M3X86_RS04355 (M3X86_04355) 861765..862172 + 408 WP_004144731.1 protein YgfX Toxin
M3X86_RS04360 (M3X86_04360) 862179..862700 - 522 WP_002916308.1 flavodoxin FldB -
M3X86_RS04365 (M3X86_04365) 862801..863697 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M3X86_RS04370 (M3X86_04370) 863720..864433 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M3X86_RS04375 (M3X86_04375) 864439..866172 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T245789 WP_004144731.1 NZ_CP097660:861765-862172 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT245789 WP_002916312.1 NZ_CP097660:861518-861784 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References