Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 727193..727968 Replicon chromosome
Accession NZ_CP097660
Organism Klebsiella pneumoniae strain IR12243_1

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag M3X86_RS03640 Protein ID WP_004150910.1
Coordinates 727483..727968 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag M3X86_RS03635 Protein ID WP_004150912.1
Coordinates 727193..727486 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X86_RS03615 (M3X86_03615) 722401..723003 - 603 WP_062954968.1 short chain dehydrogenase -
M3X86_RS03620 (M3X86_03620) 723101..724012 + 912 WP_004188550.1 LysR family transcriptional regulator -
M3X86_RS03625 (M3X86_03625) 724013..725161 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
M3X86_RS03630 (M3X86_03630) 725172..726548 - 1377 WP_004217775.1 cystathionine beta-synthase -
M3X86_RS03635 (M3X86_03635) 727193..727486 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
M3X86_RS03640 (M3X86_03640) 727483..727968 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
M3X86_RS03645 (M3X86_03645) 728672..729265 + 594 WP_004188553.1 hypothetical protein -
M3X86_RS03650 (M3X86_03650) 729362..729578 + 217 Protein_717 transposase -
M3X86_RS03655 (M3X86_03655) 730184..731056 + 873 WP_004188557.1 ParA family protein -
M3X86_RS03660 (M3X86_03660) 731125..732317 + 1193 WP_085955245.1 IS3-like element ISKpn18 family transposase -
M3X86_RS03665 (M3X86_03665) 732362..732745 + 384 WP_004150906.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T245788 WP_004150910.1 NZ_CP097660:727483-727968 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT245788 WP_004150912.1 NZ_CP097660:727193-727486 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References