Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 846094..846723 Replicon chromosome
Accession NC_013891
Organism Listeria seeligeri serovar 1/2b str. SLCC3954

Toxin (Protein)


Gene name pemK Uniprot ID A0A6Z2PJ29
Locus tag LSE_RS03950 Protein ID WP_031695189.1
Coordinates 846376..846723 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID E3ZNL6
Locus tag LSE_RS03945 Protein ID WP_003746456.1
Coordinates 846094..846372 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSE_RS03925 841407..842894 + 1488 WP_012985202.1 PH domain-containing protein -
LSE_RS03930 843027..844406 + 1380 WP_012985203.1 protoporphyrinogen oxidase -
LSE_RS03935 844408..844764 + 357 WP_012985204.1 holo-ACP synthase -
LSE_RS03940 844782..845888 + 1107 WP_012985205.1 alanine racemase -
LSE_RS03945 846094..846372 + 279 WP_003746456.1 CopG family ribbon-helix-helix protein Antitoxin
LSE_RS03950 846376..846723 + 348 WP_031695189.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LSE_RS03955 846972..847808 + 837 WP_012985206.1 STAS domain-containing protein -
LSE_RS03960 847814..848170 + 357 WP_003721457.1 STAS domain-containing protein -
LSE_RS03965 848173..848583 + 411 WP_041176161.1 anti-sigma regulatory factor -
LSE_RS03970 848600..849604 + 1005 WP_012985208.1 PP2C family protein-serine/threonine phosphatase -
LSE_RS03975 849743..850087 + 345 WP_003751701.1 anti sigma b factor antagonist RsbV -
LSE_RS03980 850071..850544 + 474 WP_003751702.1 anti-sigma B factor RsbW -
LSE_RS03985 850522..851301 + 780 WP_003721462.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12801.89 Da        Isoelectric Point: 7.2038

>T24578 WP_031695189.1 NC_013891:846376-846723 [Listeria seeligeri serovar 1/2b str. SLCC3954]
MMVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVEATRKDGFERDSVILLEQIR
TIDKQRLTDKITHLDEELMAKVNKALEVSLGVVEF

Download         Length: 348 bp

>T24578 NC_013891:846376-846723 [Listeria seeligeri serovar 1/2b str. SLCC3954]
CTGATGGTGAAGCGTGGTGACGTATACTACGCGGACCTTTCCCCCGTGGTCGGAAGCGAGCAAGGGGGAATACGGCCTGT
CCTCATCATTCAAAATGATATCGGTAATAGGTTCAGTCCAACAGTGATTGTGGCAGCGATAACTGCGAAAATCCAAAAAG
CAAAGTTGCCTACACACGTGGAAGCTACTCGTAAAGATGGCTTTGAAAGAGATTCTGTCATACTTCTAGAACAAATTAGA
ACAATTGATAAACAACGCCTGACAGATAAGATTACACATTTGGACGAGGAACTAATGGCCAAGGTAAACAAGGCGCTGGA
AGTCAGTCTAGGAGTAGTAGAATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10591.11 Da        Isoelectric Point: 4.2980

>AT24578 WP_003746456.1 NC_013891:846094-846372 [Listeria seeligeri serovar 1/2b str. SLCC3954]
VLEKEKRMVISVELTQEMVQELDVVVEKEKMGRSEVIMEATQQFLQEKRARELRDEMERGYAEMATINFAIACECTHVEA
EAEDRNISILGG

Download         Length: 279 bp

>AT24578 NC_013891:846094-846372 [Listeria seeligeri serovar 1/2b str. SLCC3954]
GTGTTAGAGAAAGAAAAGCGGATGGTAATATCCGTAGAACTGACACAGGAAATGGTACAGGAACTCGACGTAGTTGTAGA
AAAAGAAAAAATGGGGCGGAGTGAAGTTATAATGGAAGCAACGCAACAATTTTTGCAAGAGAAAAGGGCACGTGAGTTAA
GAGACGAGATGGAGCGCGGCTATGCGGAAATGGCGACAATTAACTTTGCTATTGCGTGTGAGTGTACCCATGTCGAAGCA
GAAGCAGAAGACAGGAATATTAGTATTTTAGGAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6Z2PJ29

Antitoxin

Source ID Structure
AlphaFold DB A0A7X0X0M3

References