Detailed information of TA system TA024577

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 2207699..2208817
• Replicon: chromosome
• Accession: NC_013889
• Organism: Thioalkalivibrio sp. K90mix

Toxin (Protein)

• Gene name: -
• Uniprot ID: D3SCK7
• Locus tag: TK90_RS10485
• Protein ID: WP_012983453.1
• Coordinates: 2207699..2208445 (-)
• Length: 249 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: D3SCK8
• Locus tag: TK90_RS10490
• Protein ID: WP_012983454.1
• Coordinates: 2208458..2208817 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TK90_RS10450	2202970..2203332	-	363	WP_012983448.1	nucleotide pyrophosphohydrolase	-
TK90_RS10455	2203533..2204438	-	906	WP_012983449.1	LysR family transcriptional regulator	-
TK90_RS10460	2204560..2205009	+	450	WP_012983450.1	DoxX family protein	-
TK90_RS10465	2205083..2205304	+	222	WP_017926326.1	pirin family protein	-
TK90_RS10470	2205600..2206088	+	489	Protein_2061	pirin family protein	-
TK90_RS10475	2206116..2206703	+	588	WP_012983451.1	NAD(P)H-dependent oxidoreductase	-
TK90_RS10480	2206700..2207614	+	915	WP_012983452.1	pirin family protein	-
TK90_RS10485	2207699..2208445	-	747	WP_012983453.1	RES family NAD+ phosphorylase	Toxin
TK90_RS10490	2208458..2208817	-	360	WP_012983454.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
TK90_RS10495	2209054..2209881	+	828	WP_026148232.1	M48 family metalloprotease	-
TK90_RS10500	2209894..2210220	+	327	WP_026148233.1	DUF3634 family protein	-
TK90_RS10505	2210420..2211526	+	1107	WP_012983457.1	alkene reductase	-
TK90_RS10510	2211621..2212001	+	381	WP_012983458.1	hypothetical protein	-
TK90_RS10515	2212077..2213336	+	1260	WP_012983459.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (62-209)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (69-117)

Sequences

Toxin

Protein

• Length: 249 a.a.
• Molecular weight: 28495.60 Da
• Isoelectric Point: 9.4844

>T24577 WP_012983453.1 NC_013889:c2208445-2207699 [Thioalkalivibrio sp. K90mix]
MPDWNALVEAAPRVTLRGEVLRLVESQEQVATNQLVSSLDRQAVLEEMLEATKPPRRPGTERLHYLLATPFRYPPLRHGS
RFGRRHEPSLFYGALRERTVLAEAAYYRFVFWHGMATPPARKLDTQHTLLAARYLSPDGLQLHEPPFAEHIKRLRHPADY
QATQALGAIMRESGVDLFEYASARDREAGLNLALFNARPFTRNKPTRQDPWLCQLNAECVRFLKPRDGTLYEFPLSQFLY
QGHLPLPA

Nucleotide

• Length: 747 bp

>T24577 NC_013889:c2208445-2207699 [Thioalkalivibrio sp. K90mix]
ATGCCGGACTGGAATGCGCTGGTCGAAGCCGCGCCGCGCGTCACGCTGAGAGGGGAGGTATTGCGCCTGGTCGAGAGCCA
GGAGCAGGTCGCTACCAACCAGCTCGTTTCCTCACTCGACCGTCAGGCTGTGCTGGAGGAGATGCTGGAGGCGACCAAGC
CGCCCCGGCGCCCGGGCACGGAACGGCTGCATTATCTGCTGGCGACCCCGTTTCGCTATCCGCCACTGCGCCATGGTTCG
CGCTTCGGCCGTCGCCACGAGCCCAGCCTGTTCTACGGCGCCCTGCGCGAGCGCACCGTCCTGGCCGAGGCCGCTTATTA
CCGGTTCGTCTTCTGGCACGGCATGGCGACGCCGCCAGCGCGCAAGCTGGATACACAGCACACCCTGTTGGCCGCGCGCT
ACCTGAGCCCCGATGGCCTGCAGCTCCACGAGCCTCCGTTCGCGGAACACATAAAGCGGCTGCGGCACCCCGCCGACTAC
CAGGCCACACAGGCCCTGGGTGCCATCATGCGCGAGAGCGGCGTCGACCTGTTCGAGTATGCGTCTGCCCGTGACCGCGA
GGCCGGCCTGAACCTCGCGCTCTTCAATGCGCGCCCGTTTACCCGCAACAAGCCGACGCGCCAGGACCCCTGGCTGTGCC
AGCTCAACGCGGAATGCGTCCGCTTCCTCAAGCCCCGCGACGGCACTCTGTATGAATTCCCGTTGAGCCAATTTCTTTAT
CAGGGGCACCTGCCGCTACCGGCCTGA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 12638.58 Da
• Isoelectric Point: 8.0799

>AT24577 WP_012983454.1 NC_013889:c2208817-2208458 [Thioalkalivibrio sp. K90mix]
MSVATVAVPERADVLREALVNAGKALGLTQADLGDVVGRGRTDISRGNIDPASKPGELALLLIRCYRALYVLTGGDAAAM
KHWMHTQNHHTGGVPAEQIRTVQGLVGVLEYLDAIRGKL

Nucleotide

• Length: 360 bp

>AT24577 NC_013889:c2208817-2208458 [Thioalkalivibrio sp. K90mix]
ATGAGTGTCGCAACGGTAGCCGTCCCGGAGCGCGCGGATGTCCTGCGCGAGGCGCTGGTCAATGCCGGCAAGGCGCTGGG
TCTCACCCAGGCTGATCTGGGCGACGTCGTCGGGCGCGGCCGTACGGATATCAGCCGCGGCAACATCGATCCGGCCAGCA
AGCCGGGCGAGCTGGCGCTGTTGCTGATCCGCTGCTATCGCGCGCTGTACGTCCTGACCGGCGGGGACGCCGCGGCCATG
AAACACTGGATGCACACGCAGAATCATCACACCGGCGGAGTGCCCGCCGAGCAGATCCGCACGGTGCAGGGGCTGGTGGG
CGTGCTGGAGTATCTCGACGCGATCCGCGGCAAGCTGTGA

Structures

Toxin

• AlphaFold DB: D3SCK7

Antitoxin

• AlphaFold DB: D3SCK8