Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2988065..2988719 Replicon chromosome
Accession NZ_CP097654
Organism Klebsiella pneumoniae strain IR1272_1

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag M3T50_RS14605 Protein ID WP_004144731.1
Coordinates 2988312..2988719 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M3T50_RS14600 Protein ID WP_002916312.1
Coordinates 2988065..2988331 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3T50_RS14575 (M3T50_14575) 2983221..2984654 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
M3T50_RS14580 (M3T50_14580) 2984773..2985501 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M3T50_RS14585 (M3T50_14585) 2985551..2985862 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
M3T50_RS14590 (M3T50_14590) 2986026..2986685 + 660 WP_002916317.1 hemolysin III family protein -
M3T50_RS14595 (M3T50_14595) 2986836..2987819 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
M3T50_RS14600 (M3T50_14600) 2988065..2988331 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M3T50_RS14605 (M3T50_14605) 2988312..2988719 + 408 WP_004144731.1 protein YgfX Toxin
M3T50_RS14610 (M3T50_14610) 2988726..2989247 - 522 WP_002916308.1 flavodoxin FldB -
M3T50_RS14615 (M3T50_14615) 2989348..2990244 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M3T50_RS14620 (M3T50_14620) 2990267..2990980 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M3T50_RS14625 (M3T50_14625) 2990986..2992719 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T245751 WP_004144731.1 NZ_CP097654:2988312-2988719 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT245751 WP_002916312.1 NZ_CP097654:2988065-2988331 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References