Detailed information of TA system TA024575

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 31363..31931
• Replicon: plasmid pALVIN02
• Accession: NC_013862
• Organism: Allochromatium vinosum DSM 180

Toxin (Protein)

• Gene name: parE
• Uniprot ID: D3RWG8
• Locus tag: ALVIN_RS16335
• Protein ID: WP_012979605.1
• Coordinates: 31363..31656 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D3RWG9
• Locus tag: ALVIN_RS16340
• Protein ID: WP_012979606.1
• Coordinates: 31644..31931 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ALVIN_RS16320	26900..27535	-	636	WP_043796536.1	hypothetical protein	-
ALVIN_RS16325	27991..29613	-	1623	WP_012979603.1	hypothetical protein	-
ALVIN_RS16330	29681..30781	-	1101	WP_012979604.1	hypothetical protein	-
ALVIN_RS16335	31363..31656	-	294	WP_012979605.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ALVIN_RS16340	31644..31931	-	288	WP_012979606.1	hypothetical protein	Antitoxin
ALVIN_RS16350	32467..32682	-	216	WP_043796537.1	hypothetical protein	-
ALVIN_RS16355	32642..33361	-	720	WP_012979608.1	recombinase family protein	-
ALVIN_RS16360	33582..34283	+	702	WP_012979609.1	DNA-binding protein	-
ALVIN_RS17395	34425..34778	+	354	WP_012979610.1	hypothetical protein	-
ALVIN_RS16365	34804..35211	+	408	WP_012979611.1	hypothetical protein	-
ALVIN_RS17400	35292..35861	-	570	WP_148217656.1	hypothetical protein	-
ALVIN_RS17405	35927..36409	-	483	WP_012979613.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..39929	39929

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-93)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11115.72 Da
• Isoelectric Point: 6.4726

>T24575 WP_012979605.1 NC_013862:c31656-31363 [Allochromatium vinosum DSM 180]
MPDVIWLPEAIDDLERLRAFLMDTHPKAARQAAQVIVKGASRLSDFPEIGPPMDDGTGRRELFEAFGRGGYVLRYRIDDG
RVVILRVWHAREQRETP

Nucleotide

• Length: 294 bp

>T24575 NC_013862:c31656-31363 [Allochromatium vinosum DSM 180]
ATGCCCGACGTGATCTGGCTTCCGGAAGCCATCGATGACCTGGAGCGATTACGGGCGTTCCTGATGGACACACATCCAAA
AGCTGCCCGCCAAGCCGCGCAAGTGATCGTGAAGGGGGCGAGTCGGCTGTCGGACTTCCCCGAAATTGGCCCGCCGATGG
ACGATGGAACCGGGCGACGGGAGTTATTTGAAGCCTTTGGGCGGGGTGGCTATGTTCTGAGATACCGGATCGACGACGGT
CGCGTGGTGATTCTGCGGGTGTGGCACGCCAGAGAGCAGCGCGAAACACCTTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10985.34 Da
• Isoelectric Point: 6.4705

>AT24575 WP_012979606.1 NC_013862:c31931-31644 [Allochromatium vinosum DSM 180]
MQKLVNTGVKLEAGLHQRLKVLSAAKARSPHWLMKAAIEEYVQREERYEQEKREDQERWERYQLTGRSVSQTEVSAWLST
WGDEATGEVAPPCPT

Nucleotide

• Length: 288 bp

>AT24575 NC_013862:c31931-31644 [Allochromatium vinosum DSM 180]
ATGCAAAAACTCGTCAACACGGGCGTCAAGCTCGAAGCTGGGTTGCATCAGCGTTTGAAAGTCCTGAGCGCGGCCAAGGC
CCGCAGTCCCCATTGGCTGATGAAGGCCGCCATCGAGGAGTATGTGCAGCGCGAAGAGCGCTATGAGCAGGAAAAACGGG
AGGATCAGGAGCGCTGGGAGCGCTACCAGCTCACCGGGCGTTCGGTGTCCCAGACCGAGGTCAGTGCTTGGCTGAGTACC
TGGGGGGACGAGGCGACAGGTGAGGTGGCCCCGCCATGCCCGACGTGA

Structures

Toxin

• AlphaFold DB: D3RWG8

Antitoxin

• AlphaFold DB: D3RWG9