Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 1707123..1708804 Replicon chromosome
Accession NZ_CP097654
Organism Klebsiella pneumoniae strain IR1272_1

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag M3T50_RS08310 Protein ID WP_002885155.1
Coordinates 1707123..1708040 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag M3T50_RS08315 Protein ID WP_004151732.1
Coordinates 1708046..1708804 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3T50_RS08290 (M3T50_08290) 1702429..1703949 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
M3T50_RS08295 (M3T50_08295) 1703946..1704944 + 999 WP_002885172.1 ribose ABC transporter permease -
M3T50_RS08300 (M3T50_08300) 1704975..1705916 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
M3T50_RS08305 (M3T50_08305) 1705991..1706998 + 1008 WP_004151731.1 carbohydrate kinase family protein -
M3T50_RS08310 (M3T50_08310) 1707123..1708040 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
M3T50_RS08315 (M3T50_08315) 1708046..1708804 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
M3T50_RS08320 (M3T50_08320) 1708890..1709618 - 729 WP_002885152.1 response regulator transcription factor -
M3T50_RS08325 (M3T50_08325) 1709891..1712038 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
M3T50_RS08330 (M3T50_08330) 1712268..1712954 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T245746 WP_002885155.1 NZ_CP097654:c1708040-1707123 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT245746 WP_004151732.1 NZ_CP097654:c1708804-1708046 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References