Detailed information of TA system TA024574

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 6038..6675
• Replicon: plasmid pALVIN02
• Accession: NC_013862
• Organism: Allochromatium vinosum DSM 180

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: ALVIN_RS16210
• Protein ID: WP_043796539.1
• Coordinates: 6274..6675 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: D3RWE3
• Locus tag: ALVIN_RS16205
• Protein ID: WP_012979580.1
• Coordinates: 6038..6268 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ALVIN_RS16175	1315..1530	+	216	WP_012979573.1	DUF2281 domain-containing protein	-
ALVIN_RS17365	1520..1936	+	417	WP_012979574.1	PIN domain-containing protein	-
ALVIN_RS16180	2050..3792	+	1743	WP_012979575.1	type I restriction-modification system subunit M	-
ALVIN_RS16185	3808..4032	+	225	WP_012979576.1	hypothetical protein	-
ALVIN_RS16190	4020..4445	+	426	WP_012979577.1	type II toxin-antitoxin system VapC family toxin	-
ALVIN_RS16195	4442..5803	+	1362	WP_012979578.1	restriction endonuclease subunit S	-
ALVIN_RS16200	5814..6041	+	228	WP_012979579.1	hypothetical protein	-
ALVIN_RS16205	6038..6268	+	231	WP_012979580.1	virulence factor	Antitoxin
ALVIN_RS16210	6274..6675	+	402	WP_043796539.1	type II toxin-antitoxin system VapC family toxin	Toxin
ALVIN_RS16215	6672..9803	+	3132	WP_012979582.1	type I restriction endonuclease subunit R	-
ALVIN_RS17370	10096..10518	+	423	WP_081442771.1	H-NS histone family protein	-
ALVIN_RS16220	10615..10902	-	288	WP_012979583.1	integration host factor subunit beta	-
ALVIN_RS16225	11099..11632	-	534	WP_012979584.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..39929	39929

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14937.24 Da
• Isoelectric Point: 9.5679

>T24574 WP_043796539.1 NC_013862:6274-6675 [Allochromatium vinosum DSM 180]
MRYLLDTNICIYIAKRRPPEVAGRFDSLHPGEVGMSIITYGELLLGAEKSQHPQPTKERLRRFVELVPVLSLPRESPHRY
ARIRADLERAGTPIGANDLWIAAHALTSGLILVSNNLREFGRIPGLATENWAQ

Nucleotide

• Length: 402 bp

>T24574 NC_013862:6274-6675 [Allochromatium vinosum DSM 180]
ATGCGCTATCTCCTCGACACCAACATCTGCATCTACATCGCGAAGCGGCGTCCGCCAGAGGTTGCGGGGCGATTCGACAG
CCTGCACCCTGGCGAAGTCGGGATGTCGATCATCACCTATGGCGAGTTGCTGCTCGGTGCCGAAAAGAGCCAGCATCCGC
AACCGACCAAAGAACGGTTGCGGCGGTTCGTGGAACTGGTTCCCGTGCTGTCGCTGCCACGCGAGAGTCCCCATCGCTAC
GCTCGCATCCGTGCCGACTTGGAACGCGCCGGCACGCCGATTGGTGCCAATGACTTGTGGATCGCGGCACATGCGCTGAC
CTCCGGTCTGATCCTGGTCAGCAACAATCTACGGGAGTTTGGTCGGATTCCAGGACTGGCCACGGAAAACTGGGCGCAAT
GA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8690.85 Da
• Isoelectric Point: 4.4563

>AT24574 WP_012979580.1 NC_013862:6038-6268 [Allochromatium vinosum DSM 180]
MITAKIDRRGTLQSVRLPEGFQFDVDEVEILRRGDEIVLRQKPTSLRAAFDLLASMPDDFFAEGRQDVPPETRESL

Nucleotide

• Length: 231 bp

>AT24574 NC_013862:6038-6268 [Allochromatium vinosum DSM 180]
ATGATCACCGCCAAAATTGATCGCCGTGGCACCTTACAGAGCGTGCGGCTACCCGAGGGGTTTCAGTTCGATGTTGACGA
GGTCGAGATTCTGCGCCGAGGTGACGAAATCGTGCTCCGCCAGAAGCCGACAAGCCTGCGTGCGGCATTCGACCTGTTGG
CTTCCATGCCCGACGACTTCTTCGCCGAAGGACGCCAAGACGTACCGCCCGAGACCCGCGAATCCCTGTGA

Structures

Antitoxin

• AlphaFold DB: D3RWE3