Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4851113..4851629 Replicon chromosome
Accession NZ_CP097651
Organism Klebsiella pneumoniae strain NK01067

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M8Y62_RS23280 Protein ID WP_004178374.1
Coordinates 4851113..4851397 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M8Y62_RS23285 Protein ID WP_002886901.1
Coordinates 4851387..4851629 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y62_RS23255 (4846509) 4846509..4846772 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
M8Y62_RS23260 (4846902) 4846902..4847075 + 174 WP_041169004.1 hypothetical protein -
M8Y62_RS23265 (4847078) 4847078..4847821 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M8Y62_RS23270 (4848178) 4848178..4850316 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M8Y62_RS23275 (4850645) 4850645..4851109 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M8Y62_RS23280 (4851113) 4851113..4851397 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8Y62_RS23285 (4851387) 4851387..4851629 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M8Y62_RS23290 (4851707) 4851707..4853617 - 1911 WP_012737231.1 PRD domain-containing protein -
M8Y62_RS23295 (4853640) 4853640..4854794 - 1155 WP_012737230.1 lactonase family protein -
M8Y62_RS23300 (4854861) 4854861..4855601 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T245738 WP_004178374.1 NZ_CP097651:c4851397-4851113 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT245738 WP_002886901.1 NZ_CP097651:c4851629-4851387 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References