Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4683752..4684562 Replicon chromosome
Accession NZ_CP097651
Organism Klebsiella pneumoniae strain NK01067

Toxin (Protein)


Gene name KacT Uniprot ID A0A332NV98
Locus tag M8Y62_RS22555 Protein ID WP_014908042.1
Coordinates 4683752..4684285 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag M8Y62_RS22560 Protein ID WP_002887278.1
Coordinates 4684296..4684562 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y62_RS22550 (4682583) 4682583..4683704 + 1122 WP_012737335.1 cupin domain-containing protein -
M8Y62_RS22555 (4683752) 4683752..4684285 - 534 WP_014908042.1 type II toxin-antitoxin system toxin KacT Toxin
M8Y62_RS22560 (4684296) 4684296..4684562 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
M8Y62_RS22565 (4684665) 4684665..4686098 - 1434 WP_014908043.1 Cu(+)/Ag(+) sensor histidine kinase -
M8Y62_RS22570 (4686088) 4686088..4686771 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
M8Y62_RS22575 (4686943) 4686943..4688328 + 1386 WP_012737332.1 efflux transporter outer membrane subunit -
M8Y62_RS22580 (4688346) 4688346..4688690 + 345 WP_012737331.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-150)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19795.68 Da        Isoelectric Point: 5.2614

>T245737 WP_014908042.1 NZ_CP097651:c4684285-4683752 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGLGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT245737 WP_002887278.1 NZ_CP097651:c4684562-4684296 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332NV98

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References