Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2791449..2793037 Replicon chromosome
Accession NZ_CP097651
Organism Klebsiella pneumoniae strain NK01067

Toxin (Protein)


Gene name hipA Uniprot ID A0A331XLA5
Locus tag M8Y62_RS13590 Protein ID WP_014907613.1
Coordinates 2791449..2792771 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag M8Y62_RS13595 Protein ID WP_002904790.1
Coordinates 2792771..2793037 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y62_RS13575 (2786505) 2786505..2789006 + 2502 WP_014907611.1 fimbria/pilus outer membrane usher protein -
M8Y62_RS13580 (2788994) 2788994..2789998 + 1005 WP_014907612.1 fimbrial protein -
M8Y62_RS13585 (2790140) 2790140..2791432 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
M8Y62_RS13590 (2791449) 2791449..2792771 - 1323 WP_014907613.1 type II toxin-antitoxin system HipA family toxin Toxin
M8Y62_RS13595 (2792771) 2792771..2793037 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M8Y62_RS13600 (2793275) 2793275..2793601 - 327 WP_004215084.1 hydroxyisourate hydrolase -
M8Y62_RS13605 (2793598) 2793598..2794098 - 501 WP_004184022.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M8Y62_RS13610 (2794076) 2794076..2795455 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
M8Y62_RS13615 (2795801) 2795801..2796955 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M8Y62_RS13620 (2796936) 2796936..2797859 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49139.47 Da        Isoelectric Point: 7.5367

>T245735 WP_014907613.1 NZ_CP097651:c2792771-2791449 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT245735 WP_002904790.1 NZ_CP097651:c2793037-2792771 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331XLA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References