Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2975987..2977509 Replicon chromosome
Accession NZ_CP097649
Organism Brevundimonas albigilva strain TT17

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag M8231_RS14860 Protein ID WP_250201843.1
Coordinates 2975987..2977297 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag M8231_RS14865 Protein ID WP_045811357.1
Coordinates 2977297..2977509 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8231_RS14830 (M8231_14830) 2971193..2971999 - 807 WP_250201837.1 flagellin -
M8231_RS14835 (M8231_14835) 2972171..2972614 - 444 WP_250201838.1 flagellar biosynthesis repressor FlbT -
M8231_RS14840 (M8231_14840) 2973223..2973744 - 522 WP_250201839.1 DUF922 domain-containing protein -
M8231_RS14845 (M8231_14845) 2973885..2974481 - 597 WP_250201840.1 MerR family transcriptional regulator -
M8231_RS14850 (M8231_14850) 2974597..2975016 + 420 WP_250201841.1 hypothetical protein -
M8231_RS14855 (M8231_14855) 2975079..2975990 + 912 WP_250201842.1 site-specific integrase -
M8231_RS14860 (M8231_14860) 2975987..2977297 - 1311 WP_250201843.1 type II toxin-antitoxin system HipA family toxin Toxin
M8231_RS14865 (M8231_14865) 2977297..2977509 - 213 WP_045811357.1 helix-turn-helix domain-containing protein Antitoxin
M8231_RS14875 (M8231_14875) 2977913..2978269 - 357 WP_054764657.1 response regulator -
M8231_RS14880 (M8231_14880) 2978384..2979208 + 825 WP_250201844.1 N-formylglutamate amidohydrolase -
M8231_RS14885 (M8231_14885) 2979479..2980162 - 684 WP_249749384.1 DUF599 family protein -
M8231_RS14890 (M8231_14890) 2980305..2980865 + 561 WP_250201845.1 inorganic diphosphatase -
M8231_RS14895 (M8231_14895) 2980989..2982290 + 1302 WP_250201846.1 ATP-dependent protease ATPase subunit HslU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2936678..2983473 46795


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(139-370)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-46)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 46282.98 Da        Isoelectric Point: 6.7679

>T245727 WP_250201843.1 NZ_CP097649:c2977297-2975987 [Brevundimonas albigilva]
MPVLFHRDSPVAKVTPSPAGLNLIYDETWRASPEAFPVSLSMPMAEAAWPPEVVVPWVMNLLPEGEPMRAMQRALGVAQE
DVLGLLSAAGGDVAGALRVGGPRAEQGDYRPLPTPDDLERIIGELPRKPFLAGDKGVTMSLAGAQDKLPVALLNGQIVIP
LDGAPSTHILKPDNPRLPGSVQNEALCMLLAARCRLPTASVTTGRAGDRSYLLVDRYDRAGHAPAATRLHQEDFCQALRL
PPGAKYERNQTGVRGPSLADMFALVRRHMTAVDITRLLDAVIFNIAIGNVDSHAKNYSILLTADGAALAPLYDLMSGLPW
PGITQNHAQAVGGQVRGRHIQARHWRRMAEACGLAPAATVRRVIALTDRIQREIGAAAEAVAAMPAGGGAFLDGLMRNIT
ERAALVGRNAARDDGGDDADGEGPAVRGEAFPSSSN

Download         Length: 1311 bp

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7349.49 Da        Isoelectric Point: 10.9613

>AT245727 WP_045811357.1 NZ_CP097649:c2977509-2977297 [Brevundimonas albigilva]
MIVTAEDFGRQVAEARRALGLTQRDLALAIGTGERFIVELEAGKATAQLGKALAAAKAVGVRLENTAGRR

Download         Length: 213 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References