Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1948674..1950316 Replicon chromosome
Accession NZ_CP097649
Organism Brevundimonas albigilva strain TT17

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag M8231_RS09735 Protein ID WP_250201369.1
Coordinates 1949024..1950316 (+) Length 431 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag M8231_RS09730 Protein ID WP_250201368.1
Coordinates 1948674..1949027 (+) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8231_RS09710 (M8231_09710) 1944156..1944926 - 771 WP_250201364.1 hypothetical protein -
M8231_RS09715 (M8231_09715) 1944985..1947030 - 2046 WP_250201365.1 ParB/RepB/Spo0J family partition protein -
M8231_RS09720 (M8231_09720) 1947401..1947889 + 489 WP_250201366.1 hypothetical protein -
M8231_RS09725 (M8231_09725) 1948038..1948430 - 393 WP_250201367.1 hypothetical protein -
M8231_RS09730 (M8231_09730) 1948674..1949027 + 354 WP_250201368.1 helix-turn-helix domain-containing protein Antitoxin
M8231_RS09735 (M8231_09735) 1949024..1950316 + 1293 WP_250201369.1 type II toxin-antitoxin system HipA family toxin Toxin
M8231_RS09740 (M8231_09740) 1950333..1951688 - 1356 WP_250201370.1 hypothetical protein -
M8231_RS09745 (M8231_09745) 1951685..1952050 - 366 WP_250201371.1 hypothetical protein -
M8231_RS09750 (M8231_09750) 1952160..1952666 - 507 WP_250201372.1 nuclease -
M8231_RS09755 (M8231_09755) 1952656..1953033 - 378 WP_250201373.1 hypothetical protein -
M8231_RS09760 (M8231_09760) 1953241..1953513 - 273 Protein_1904 transposase family protein -
M8231_RS09765 (M8231_09765) 1953955..1955097 + 1143 WP_250201374.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-116)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-67)


Sequences

Toxin        


Download         Length: 431 a.a.        Molecular weight: 47648.93 Da        Isoelectric Point: 5.5117

>T245723 WP_250201369.1 NZ_CP097649:1949024-1950316 [Brevundimonas albigilva]
MTTVAEVRLWGSRIGAVSLEDGAETAAFAYDPAFAESNIQVAPLVMPLSRQTYTFPSLNPETFQGLPGLLADALPDRYGN
TLINAWLATQGRTPESFNAVERLCYTGARGMGALEFTPAKGPQAKTSQKIQIDRLVALASEVLTHQNDLDTSFASKGDAL
RDILRVGTSAGGARAKAVIAWNPATNEVRSGQVDAGEGFEYWLLKFDGVSNNKDRGLADPKGFGAVEFAYSEMARAAGIE
MAPCRLLEEGGRRHFMTQRFDRTPQGKLHMQSLGAIAHFDYGQPTTYTYEQAFLVLRQMDLPMSDLEQLFRRMAFNIVAR
NQDDHVKNVAFLMDKTGRWSLSPAYDVTWSFDPGNKWLSQHQMAMNGKRDGFVLADFEDCARTVSINSARARAIVQEVRD
VVADWPRFAEVAQVDDKMRLDIDPSLRLML

Download         Length: 1293 bp

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13268.16 Da        Isoelectric Point: 10.2683

>AT245723 WP_250201368.1 NZ_CP097649:1948674-1949027 [Brevundimonas albigilva]
MKLTALNTDEAVLGELGRRLTDHRIVRELTQAQVAEAAGVSKRTIERLEAGESVQFSNLIRVMRVLDRLDGFDRLLPEAP
ANPIDLLERQGKVRQRVRPDGGSSEPIHMRWSWGDKR

Download         Length: 354 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References