245720

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 37909..38431 Replicon plasmid pKqu-1
Accession NZ_CP097647
Organism Klebsiella quasipneumoniae strain NE1

Toxin (Protein)


Gene name stbE Uniprot ID A0A9J6S4Z8
Locus tag M8232_RS25020 Protein ID WP_004187019.1
Coordinates 37909..38193 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4ZSR4
Locus tag M8232_RS25025 Protein ID WP_004187025.1
Coordinates 38183..38431 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8232_RS24990 (M8232_24990) 33269..33697 + 429 WP_035897523.1 glutaredoxin-dependent arsenate reductase -
M8232_RS24995 (M8232_24995) 33983..34771 + 789 Protein_43 ISNCY family transposase -
M8232_RS25000 (M8232_25000) 34860..36088 + 1229 WP_094081435.1 IS3 family transposase -
M8232_RS25005 (M8232_25005) 36101..36277 + 177 Protein_45 transposase -
M8232_RS25015 (M8232_25015) 37501..37893 + 393 Protein_47 transposase -
M8232_RS25020 (M8232_25020) 37909..38193 - 285 WP_004187019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8232_RS25025 (M8232_25025) 38183..38431 - 249 WP_004187025.1 plasmid stabilization protein Antitoxin
M8232_RS25030 (M8232_25030) 38806..39204 - 399 WP_049084174.1 helix-turn-helix domain-containing protein -
M8232_RS25035 (M8232_25035) 39253..40599 - 1347 WP_250202749.1 ISNCY family transposase -
M8232_RS25040 (M8232_25040) 40719..41498 + 780 WP_250202743.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - mrkA / mrkB / mrkC / mrkF / mrkJ / pla 1..181209 181209
- inside IScluster/Tn - - 34860..43442 8582


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11003.72 Da        Isoelectric Point: 10.5388

>T245720 WP_004187019.1 NZ_CP097647:c38193-37909 [Klebsiella quasipneumoniae]
MTYKLAFNESALKEWKKLGHTLQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGVGK
RENDDIYNATLNRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9011.24 Da        Isoelectric Point: 3.9947

>AT245720 WP_004187025.1 NZ_CP097647:c38431-38183 [Klebsiella quasipneumoniae]
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZSR4

References