245719

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 23998..24908 Replicon plasmid pKqu-1
Accession NZ_CP097647
Organism Klebsiella quasipneumoniae strain NE1

Toxin (Protein)


Gene name - Uniprot ID A0A2A5MBW7
Locus tag M8232_RS24940 Protein ID WP_023329005.1
Coordinates 24438..24908 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A9J6S5L1
Locus tag M8232_RS24935 Protein ID WP_049084156.1
Coordinates 23998..24441 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8232_RS24910 (M8232_24910) 19890..20120 - 231 Protein_26 hypothetical protein -
M8232_RS24915 (M8232_24915) 20319..21040 + 722 Protein_27 DUF969 domain-containing protein -
M8232_RS24920 (M8232_24920) 21037..22023 + 987 Protein_28 DUF979 domain-containing protein -
M8232_RS24925 (M8232_24925) 22033..23028 + 996 WP_032731961.1 DUF2891 domain-containing protein -
M8232_RS24930 (M8232_24930) 23210..23876 + 667 Protein_30 DUF4113 domain-containing protein -
M8232_RS24935 (M8232_24935) 23998..24441 + 444 WP_049084156.1 DUF2384 domain-containing protein Antitoxin
M8232_RS24940 (M8232_24940) 24438..24908 + 471 WP_023329005.1 RES family NAD+ phosphorylase Toxin
M8232_RS24945 (M8232_24945) 25211..26179 - 969 WP_000654811.1 IS5 family transposase -
M8232_RS24950 (M8232_24950) 26197..26343 - 147 WP_250202739.1 hypothetical protein -
M8232_RS24955 (M8232_24955) 27038..28413 + 1376 WP_250202740.1 IS3 family transposase -
M8232_RS24960 (M8232_24960) 28662..29237 - 576 WP_032731970.1 cytochrome b/b6 domain-containing protein -
M8232_RS24965 (M8232_24965) 29385..29690 + 306 WP_023328906.1 metalloregulator ArsR/SmtB family transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - mrkA / mrkB / mrkC / mrkF / mrkJ / pla 1..181209 181209


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre

(16-147)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17459.70 Da        Isoelectric Point: 4.4829

>T245719 WP_023329005.1 NZ_CP097647:24438-24908 [Klebsiella quasipneumoniae]
VILYRLTKTKNLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPANWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHSDFYGIVQMAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16447.80 Da        Isoelectric Point: 10.2498

>AT245719 WP_049084156.1 NZ_CP097647:23998-24441 [Klebsiella quasipneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAALKWLNEPNRALSWKVPADLIASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBW7

Antitoxin

Source ID Structure

References