Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4604048..4604561 Replicon chromosome
Accession NZ_CP097646
Organism Klebsiella quasipneumoniae strain NE1

Toxin (Protein)


Gene name relE Uniprot ID A0A663BE04
Locus tag M8232_RS22220 Protein ID WP_017900571.1
Coordinates 4604048..4604329 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M8232_RS22225 Protein ID WP_002886901.1
Coordinates 4604319..4604561 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8232_RS22205 (4599090) 4599090..4600745 + 1656 WP_122542084.1 alpha,alpha-phosphotrehalase -
M8232_RS22210 (4601131) 4601131..4603269 + 2139 WP_004206513.1 anaerobic ribonucleoside-triphosphate reductase -
M8232_RS22215 (4603580) 4603580..4604044 + 465 WP_050533674.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M8232_RS22220 (4604048) 4604048..4604329 - 282 WP_017900571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8232_RS22225 (4604319) 4604319..4604561 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M8232_RS22230 (4604639) 4604639..4606549 - 1911 WP_004206509.1 PRD domain-containing protein -
M8232_RS22235 (4606572) 4606572..4607723 - 1152 WP_156234634.1 lactonase family protein -
M8232_RS22240 (4607791) 4607791..4608531 - 741 WP_017900574.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(18-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11082.93 Da        Isoelectric Point: 10.4123

>T245718 WP_017900571.1 NZ_CP097646:c4604329-4604048 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDRVVVVYVIAIGKR
EKAAVYHQANKRL

Download         Length: 282 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT245718 WP_002886901.1 NZ_CP097646:c4604561-4604319 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663BE04

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References