245710

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1550606..1552398 Replicon chromosome
Accession NZ_CP097646
Organism Klebsiella quasipneumoniae strain NE1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag M8232_RS07515 Protein ID WP_064178420.1
Coordinates 1551049..1552398 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M8232_RS07510 Protein ID WP_064178387.1
Coordinates 1550606..1551052 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8232_RS07495 (1546901) 1546901..1547899 + 999 WP_004201626.1 galactose/glucose ABC transporter substrate-binding protein MglB -
M8232_RS07500 (1548018) 1548018..1549538 + 1521 WP_004201625.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
M8232_RS07505 (1549554) 1549554..1550564 + 1011 WP_002912871.1 galactose/methyl galactoside ABC transporter permease MglC -
M8232_RS07510 (1550606) 1550606..1551052 - 447 WP_064178387.1 helix-turn-helix transcriptional regulator Antitoxin
M8232_RS07515 (1551049) 1551049..1552398 - 1350 WP_064178420.1 HipA domain-containing protein Toxin
M8232_RS07520 (1552513) 1552513..1553244 - 732 WP_008804033.1 outer membrane permeability protein SanA -
M8232_RS07525 (1553520) 1553520..1554404 - 885 WP_053810132.1 cytidine deaminase -
M8232_RS07530 (1554533) 1554533..1555228 - 696 WP_004201621.1 CidB/LrgB family autolysis modulator -
M8232_RS07535 (1555218) 1555218..1555622 - 405 WP_004201620.1 CidA/LrgA family protein -
M8232_RS07540 (1555980) 1555980..1556912 + 933 WP_004201619.1 tRNA dihydrouridine(16) synthase DusC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-410)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51050.94 Da        Isoelectric Point: 4.8038

>T245710 WP_064178420.1 NZ_CP097646:c1552398-1551049 [Klebsiella quasipneumoniae]
METLTVQAFLNAEWQDIALIKFPGSEQGDWFTTQIDYLTDYAIDFLERDDYHAVSLNHPVSLYFEDHGNPGWLRFIDDII
PSGASRRYWVNFLDISELPQGQQNFILLKFGTMSPVGNLRIKDSVPDWDSLASSKTFSVTDVMNRASDFLDYAQERGAAA
GGATGAGGEAPKLLLRCSKRQEIWIDTWQNEPGSDDLYYLVKYPRGSRSEVDCNILRAEFHYYHELTAMGFSTIPVDNMR
LEEGLHYPSLWLPRFDIRRDGDGRIMRLGMESVYSLLQKAPATILDHETTLRILIEKITSSHMVRVQNYRFDVQGFIIDW
VRRDLLNIIFGNSDNHGRNTAFMKADNEITLAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWIAPDT
LLNALRETASQLIDLPSRLKARGVPVQILEMPSIGFKFIPDKLARWGLL

Download         Length: 1350 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16510.20 Da        Isoelectric Point: 10.5137

>AT245710 WP_064178387.1 NZ_CP097646:c1551052-1550606 [Klebsiella quasipneumoniae]
MKTLNKKETEIQNTLARLRAENPPSLPATEVTATEKKARSEISRQRVSTGLKKVKTIDRQAVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIFKPFGLETGLVPISKTLISSLFK

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References