Detailed information of TA system
Overview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-couple_hipB |
Location | 1550606..1552398 | Replicon | chromosome |
Accession | NZ_CP097646 | ||
Organism | Klebsiella quasipneumoniae strain NE1 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | - |
Locus tag | M8232_RS07515 | Protein ID | WP_064178420.1 |
Coordinates | 1551049..1552398 (-) | Length | 450 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | M8232_RS07510 | Protein ID | WP_064178387.1 |
Coordinates | 1550606..1551052 (-) | Length | 149 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M8232_RS07495 (1546901) | 1546901..1547899 | + | 999 | WP_004201626.1 | galactose/glucose ABC transporter substrate-binding protein MglB | - |
M8232_RS07500 (1548018) | 1548018..1549538 | + | 1521 | WP_004201625.1 | galactose/methyl galactoside ABC transporter ATP-binding protein MglA | - |
M8232_RS07505 (1549554) | 1549554..1550564 | + | 1011 | WP_002912871.1 | galactose/methyl galactoside ABC transporter permease MglC | - |
M8232_RS07510 (1550606) | 1550606..1551052 | - | 447 | WP_064178387.1 | helix-turn-helix transcriptional regulator | Antitoxin |
M8232_RS07515 (1551049) | 1551049..1552398 | - | 1350 | WP_064178420.1 | HipA domain-containing protein | Toxin |
M8232_RS07520 (1552513) | 1552513..1553244 | - | 732 | WP_008804033.1 | outer membrane permeability protein SanA | - |
M8232_RS07525 (1553520) | 1553520..1554404 | - | 885 | WP_053810132.1 | cytidine deaminase | - |
M8232_RS07530 (1554533) | 1554533..1555228 | - | 696 | WP_004201621.1 | CidB/LrgB family autolysis modulator | - |
M8232_RS07535 (1555218) | 1555218..1555622 | - | 405 | WP_004201620.1 | CidA/LrgA family protein | - |
M8232_RS07540 (1555980) | 1555980..1556912 | + | 933 | WP_004201619.1 | tRNA dihydrouridine(16) synthase DusC | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 450 a.a. Molecular weight: 51050.94 Da Isoelectric Point: 4.8038
>T245710 WP_064178420.1 NZ_CP097646:c1552398-1551049 [Klebsiella quasipneumoniae]
METLTVQAFLNAEWQDIALIKFPGSEQGDWFTTQIDYLTDYAIDFLERDDYHAVSLNHPVSLYFEDHGNPGWLRFIDDII
PSGASRRYWVNFLDISELPQGQQNFILLKFGTMSPVGNLRIKDSVPDWDSLASSKTFSVTDVMNRASDFLDYAQERGAAA
GGATGAGGEAPKLLLRCSKRQEIWIDTWQNEPGSDDLYYLVKYPRGSRSEVDCNILRAEFHYYHELTAMGFSTIPVDNMR
LEEGLHYPSLWLPRFDIRRDGDGRIMRLGMESVYSLLQKAPATILDHETTLRILIEKITSSHMVRVQNYRFDVQGFIIDW
VRRDLLNIIFGNSDNHGRNTAFMKADNEITLAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWIAPDT
LLNALRETASQLIDLPSRLKARGVPVQILEMPSIGFKFIPDKLARWGLL
METLTVQAFLNAEWQDIALIKFPGSEQGDWFTTQIDYLTDYAIDFLERDDYHAVSLNHPVSLYFEDHGNPGWLRFIDDII
PSGASRRYWVNFLDISELPQGQQNFILLKFGTMSPVGNLRIKDSVPDWDSLASSKTFSVTDVMNRASDFLDYAQERGAAA
GGATGAGGEAPKLLLRCSKRQEIWIDTWQNEPGSDDLYYLVKYPRGSRSEVDCNILRAEFHYYHELTAMGFSTIPVDNMR
LEEGLHYPSLWLPRFDIRRDGDGRIMRLGMESVYSLLQKAPATILDHETTLRILIEKITSSHMVRVQNYRFDVQGFIIDW
VRRDLLNIIFGNSDNHGRNTAFMKADNEITLAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWIAPDT
LLNALRETASQLIDLPSRLKARGVPVQILEMPSIGFKFIPDKLARWGLL
Download Length: 1350 bp
Antitoxin
Download Length: 149 a.a. Molecular weight: 16510.20 Da Isoelectric Point: 10.5137
>AT245710 WP_064178387.1 NZ_CP097646:c1551052-1550606 [Klebsiella quasipneumoniae]
MKTLNKKETEIQNTLARLRAENPPSLPATEVTATEKKARSEISRQRVSTGLKKVKTIDRQAVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIFKPFGLETGLVPISKTLISSLFK
MKTLNKKETEIQNTLARLRAENPPSLPATEVTATEKKARSEISRQRVSTGLKKVKTIDRQAVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIFKPFGLETGLVPISKTLISSLFK
Download Length: 447 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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